教育經曆:

1989-1993，博士，北京大學細胞生物學專業
1983-1986，碩士，南京農業大學組織學與胚胎學專業

工作經曆:

2005 - 至今，特聘教授
2002 - 至今，beat365官方网站教授
1993 - 2002，beat365官方网站副教授
1999 - 2002，CRC Senior Traveling Research Fellow，英國丹迪大學.
1997 - 1999，BBSRC Senior Research Fellow，英國曼徹斯特大學
1995 - 1997，Wellcome Trust Senior Traveling Research Fellow，英國丹迪大學

社會服務工作:

國家自然科學基金委第三屆和第四屆生命科學部專家咨詢委員會委員；
國家自然科學基金委第十一屆和第十二屆生命科學部專家評審組成員；
國務院學位委員會第六屆和第七屆學科評議組生物學組成員 ；
中國細胞生物學會資深理事；
中國生物物理學會常務理事；
中國生物物理學會第十屆膜與細胞生物物理專業委員會副理事長；
教育部重點實驗室主任；

榮譽獎勵:

《細胞生物學》（第5版, 丁明孝，王喜忠，張傳茂，陳建國 主編）獲首屆全國教材建設獎（高等教育類）一等獎, 2021；
《 分子細胞生物學》（第3版, 陳晔光，張傳茂，陳佺 主編）獲首屆全國教材建設獎（高等教育類）二等獎，2021；
全國高校自然科學獎一等獎（第一完成人），2020；
科技部幹細胞專項首席，2017；
北京大學拜耳學者獎，2015；
全國優秀科技工作者，2014；
北京市優秀博士學位論文指導教師獎；2011；
全國模範教師，2009；
北京市優秀教師，2009；
國家自然科學基金委員會“創新研究群體” I期（2005）和II期（2008）學術帶頭人；
國務院政府特殊津貼獲得者，2008；
北京市級高等教育教學成果獎一等獎(丁明孝,陳建國,張傳茂,蘇都莫日根) ，2004；
《細胞生物學》全國高校精品課(丁明孝,陳建國,張傳茂,蘇都莫日根等），2003；
國家自然科學基金委員會“國家傑出青年科學基金”獲得者，2003；
《細胞生物學》全國優秀教材獎一等獎(編者之一），2002；
中國國家自然科學獎二等獎（翟中和,張傳茂,張博等七人），2001；
中國高校科學技術獎一等獎（翟中和,張傳茂,張博等五人），2000；

雜志任職:

編委，Cell Research （中國），2006 - ； 編委，The Journal of Biological Chemistry，2016 - ； Associate editor，Biophysics Reports （中國），2014 - ； Review Editor，Frontiers in Cell and Developmental Biology（Switzerland），2014 -

書籍編撰:

1. 丁明孝，王喜忠，張傳茂，陳建國主編，《細胞生物學》第五版， 北京，高等教育出版社，2019。 2. 陳晔光，張傳茂，陳佺主編，《分子細胞生物學》第三版，北京，高等教育出版社，2019。 3. Shijiao Huang and Chuanmao Zhang, Chapter 11 The Coordination between DNA Replication Initiation and Other Cell Cycle Events. In: DNA Replication-Current Advances (Ed: Hervé Seligmann), Croatia: InTech Open Access Publisher, 2011, pp.233-252. 4. 張傳茂，盧智剛，《生物膜》（楊福愉主編）第一版，第19章 Ran GTPase及其結合蛋白在核膜裝配過程中的調控作用,科學出版社 2005：226-234。 5. 王喜忠，丁明孝，張傳茂，楊玉華主譯《分子細胞生物學》第三版，高等教育出版社，2005。原著：Gerald Karp: Cell and Molecular Biology： Concepts and Experiments (3ed). John Wiley & Sons, Inc.，2002。 6. Clarke, PR and Zhang, CM.， Chapter 11: Spatial and Temporal Control of Nuclear Envelope Assembly by Ran GTPase. In: The Nuclear Envelope (Ed: D.E. Evans, C. Huchison & J.A. Bryant), Garland Science/Bios Scienctific Publishers, 2004, pp.193-203. 7. Zhang, C., and Clarke, P. R., Chapter 5: Role of Ran GTPase in Nuclear Envelope Assembly. In Nuclear Envelope Dynamics in Embryos and Somatic Cells (Ed: Philippe Collas), Eurekah.com and Kluwer Academic/Plenum Publishers, 2002, pp.61-71.

執教課程:

細胞生物學 , 講課 , 北京大學 , 2002-至今，秋季
Bio2000，講課，北京大學，2005 - 2016，春季
基礎動物組織學，講課，北京大學，2012-至今， 秋季

      本實驗室主要研究方向：
　　1.幹細胞增殖與分化；
　　2.細胞核結構、動态變化與功能；
　　3.細胞周期調控機理（包括紡錘體裝配和核膜裝配機理等）；
　　4.Ran GTP酶系統的功能調控；
　　5.腫瘤細胞增殖調控。

1. Tai L*, Zhu Y*, Ren H*, Huang X, Zhang C*, Sun F*. 8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI. Protein Cell. 2022;10.1007/s13238-021-00895-y. doi:10.1007/s13238-021-00895-y
2. Mengjie Sun, Mingkang Jia, He Ren, Biying Yang, Wangfei Chi, Guangwei Xin, Qing Jiang & Chuanmao Zhang*, NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation, NATURE COMMUNICATIONS, 2021, 12:7157 | https://doi.org/10.1038/s41467-021-27528-6.
3. Tenghan Zhuang*, Boyan Zhang, Yihong Song, Fan Huang, Wangfei Chi, Guangwei Xin, Ziyu Zhang, Steven Y. Cheng, Qing Jiang, and Chuanmao Zhang*, Sufu negatively regulates both initiations of centrosome duplication and DNA replication, PNAS, 2021, Vol. 118 No. 28 e2026421118.
4.Wangfei Chi, Gang Wang, Guangwei Xin, Qing Jiang, Chuanmao Zhang* ,PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations, J Cell Biol, 2021, 220 (1): e202002151. https://doi.org/10.1083/jcb.202002151
5. Qiaoyu Lin, Bin Yu, Xiangyang Wang, Shicong Zhu, Gan Zhao, Mingkang Jia, Fan Huang, Nan Xu, He Ren, Qing Jiang, and Chuanmao Zhang*, K6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells, PNAS, 2020,117(19): 10378-10387.
6. Guangwei Xin, Jingyan Fu, Jia Luo, Zhaoxuan Deng, Qing Jiang, and Chuanmao Zhang*, Aurora B regulates PP1γ–Repo-Man interactions to maintain the chromosome condensation state, J. Biol. Chem., 2020, 295(43) :14780–14788.
7. Boyan Zhang, Tenghan Zhuang, Qiaoyu Lin, Biying Yang, Xiaowei Xu, Guangwei Xin, Shicong Zhu, Gang Wang,Bin Yu, Tingting Zhang, Qing Jiang, and Chuanmao Zhang*, Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation, PNAS, 2019,116(3): 874-879.
8. Tingting Zhang, Guangwei Xin, Mingkang Jia, Tenghan Zhuang, Shicong Zhu, Boyan Zhang, Gang Wang, Qing Jiang and Chuanmao Zhang*，The Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1，Journal of Cell Science, 2019, 132, jcs220384. doi:10.1242/jcs.220384.
9. Jia Luo, Biying Yang, Guangwei Xin, Mengjie Sun, X Boyan Zhang, Xiao Guo, Qing Jiang, and Chuanmao Zhang*, The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules, J. Biol. Chem., 2019, 294(14) 5643–5656.
10 He Ren*, Guangwei Xin*, Mingkang Jia, Shicong Zhu, Qiaoyu Lin, Xiangyang Wang, Qing Jiang, and Chuanmao Zhang*, Postmitotic annulate lamellae assembly contributes to nuclear envelope reconstitution in daughter cells. J. Biol. Chem., 2019, 294(27): 10383–10391.
11. Li Guo, Khamsah Suryati Mohd, He Ren, Guangwei Xin, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of importin-α1 by CDK1–cyclin B1 controls mitotic spindle assembly Journal of Cell Science , 2019, 132, jcs232314. doi:10.1242/jcs.232314.
12. Fu Jingyan*, Zhang Chuanmao*, Super-resolution microscopy: successful applications in centrosome study and beyond. Biophysics Reports ,2019, 5(5-6):235-243.
13. Xiaowei Xu*, Shijiao Huang*, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li , Qing Jiang and Chuanmao Zhang*, DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6, Nature Communication, 2017, | 8:15164 | DOI: 10.1038/ncomms15164 |
14. Huabo Chen*, Xiaowei Xu*, Guopeng Wang*, Boyan Zhang, Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, Hongyin Zhang and Chuanmao Zhang*, CDK4 is degraded by APC/C in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells, Journal of Biological Chemistry, 2017, http://www.jbc.org/cgi/doi/10.1074/jbc.M116.773226
15. Boyan Zhang, Gang Wang, Xiaowei Xu, Sisi Yang, Tenghan Zhuang, Guopeng Wang, He Ren,Steven Y. Cheng, Qing Jiang, and Chuanmao Zhang*,DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. Journal of Biological Chemistry, 2017, 292(4): 1351–1360.
16. Junjun Liu* and Chuanmao Zhang*, The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation, Cell. Mol. Life Sci., 2017, DOI 10.1007/s00018-017-2457-5.
17. Tan Qin, Fangjin Chen, Xiaolong Zhuo, Xiao Guo, Taikangxiang Yun, Ying Liu, Chuanmao Zhang*, and Luhua Lai* Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells. Journal of Medicinal Chemistry, 2016, 59: 7089−7096.
18. Wanqing Du, Qian Peter Su, Yang Chen, Yueyao Zhu, Dong Jiang, Yueguang Rong, Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun*, and Li Yu,* Kinesin 1 Drives Autolysosome Tubulation. Development Cell, 2016, 37( 4):326–336.
19. Xiaowei Xu, Jia Luo, Qing Jiang, and Chuanmao Zhang*, Mitotic Spindle Assembly: The Roles of Microtubule Nucleation and Assembly, 2016, In: eLS. John Wiley & Sons, Ltd:Chichester.DOI: 10.1002/9780470015902.a0022518.
20. Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang, Chuanmao Zhang*, DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. Journal of Cell Science, 2016, 129: 1429-1440 doi:10.1242/jcs.178723.
21. Boyan Zhang, Tingting Zhang, Guopeng Wang, Gang Wang, Wangfei Chi, Qing Jiang, Chuanmao Zhang* , GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis. PLoS Biology, 2015, 13(4): e1002129. doi:10.1371/journal.pbio.1002129.
22. Jingyan Fu,* Minglei Bian,* Guangwei Xin, Zhaoxuan Deng,Jia Luo,Xiao Guo, Hao Chen,Yao Wang, Qing Jiang, and Chuanmao Zhang* , TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. Journal of Cell Biology, 2015, 210 (3): 373–383.
23. Xiaolong Zhuo,* Xiao Guo,* Xiaoyan Zhang, Guihua Jing, Yao Wang, Qiang Chen, Qing Jiang, Junjun Liu,* and Chuanmao Zhang* , Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. Journal of Cell Biology, 2015, 210 (5): 727–735.
24. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou*, Qing Jiang*, and Chuanmao Zhang*, Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B. Journal of Biological Chemistry, 2015, 290(28):17546–17558.
25. Ran Q,* Nan Xu,* Gang Wang, He Ren, Si Li, Jun Lei, Qiaoyu Lin, LihaoWang, Xin Gu, Hongyin Zhang, Qing Jiang,* and Chuanmao Zhang* , The lamin-A/C–LAP2–BAF1 protein complex regulates mitotic spindle assembly and positioning. Journal of Cell Science, 2015, 128: 2830-2841.
26. Wu, Yiran、Zhuo, Xiaolong、Dai, Ziwei、Guo, Xiao、Wang, Yao、Zhang, Chuanmao*、Lai, Luhua*，Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations. Mol Biosyst, 2015, 11(2): 497-505.
27. Zhang, Meiling; Sun, Tao; Jian, Chongshu; Lei, Lei; Han, Peidong; Lv, Quanlong; Yang, Ran; Zhou, Xiaohai; Xu, Jiejia; Hu, Yingchun; Men, Yongfan; Huang, Yanyi; Zhang, Chuanmao; Zhu, Xiaojun; Wang, Xianhua; Cheng, Heping; Xiong, Jing-Wei* , Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. PLos One, 2015, 10(7), p e0132567.
28. Gang Wang, Qing Jiang and Chuanmao Zhang*, The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. Journal of Cell Science, 2014,127:4111-4122.
29. Han, Peidong;Zhou, Xiao-Hai;Chang, Nannan;Xiao, Cheng-Lu;Yan, Shouyu;Ren, He;Yang, Xin-Zhuang;Zhang, Mei-Ling;Wu, Qing;Tang, Boyang;Diao, Ju-Peng;Zhu, Xiaojun;Zhang, Chuanmao;Li, Chuan-Yun;Cheng, Heping;Xiong, Jing-Wei*, Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Research, 2014, 24(9),1091-1107.
30. Zhige Wu, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of Crm1 by CDK1–cyclin-B promotes Ran-dependent mitotic spindle assembly, Journal of Cell Science, 2013, 126 (15)：3417–3428.
31. Gang Wang, Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang and Chuanmao Zhang*, PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry, Journal of Cell Science, 2013, 126 (6)： 1355–1365.
32. Wenxiang Fu, Hao Chen, GangWang, Jia Luo, Zhaoxuan Deng, Guangwei Xin, Nan Xu, Xiao Guo, Jun Lei, Qing Jiang and Chuanmao Zhang*, Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly, Proc. Natl. Acad. Sci. USA (PNAS), 2013, 110 (38) : 15295–15300.
33. Quanlong Lu, Zhigang Lu, Qinying Liu , Li Guo, He Ren, Jingyan Fu, Qing Jiang, Paul R Clarke, Chuanmao Zhang*, Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β. Cell Research, 2012, 22:1562-1575.
34. Yueguang Rong; Yuan Tian; Jianzhong Xi; Chuanmao Zhang; Hanshuo Zhang; Zhen Cao; She Chen; Wanqing Du; Lin Li; Ying Li; Mei Liu; Liang Ma; He Ren; Li Yu*, Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nature Cell Biology, 2012, 14(9):924-934.
35. Shiqi Wang; Weiming Xiao; Chuanmao Zhang; Yan Zhang; Juan Chen; Ming Chen; Quan Chen; Chunsun Jiang; Shouqin Lü; Sicong Shan; Mian Long*, Multi-patterned dynamics of mitochondrial fission and fusion in a living cell. PloS one, 2012, 7(5):e19879.
36. Hao-Di Wu, Ming Xu, Rong-Chang Li, Liang Guo, Ying-Si Lai, Shi-Ming Xu,Su-Fang Li, Quan-Long Lu , Lin-Lin Li, Hai-Bo Zhang, You-Yi Zhang, Chuan-Mao Zhang, and Shi-Qiang Wang*, Ultrastructural remodelling of Ca21 signalling apparatus in failing heart cells. Cardiovascular Research, 2012, 95, 430–438.
37. Wenxiang Fu, Qing Jiang and Chuanmao Zhang*, Novel functions of endocytic player clathrin in mitosis. Cell Research, 2011, 21:1655-1661.
38. Xiu-Hua Xue, Chun-Qing Guo, Fei Du, Quan-Long Lu, Chuanmao Zhang and Hai-Yun Ren*, AtFH8 Is Involved in Root Development under Effect of Low-Dose Latrunculin B in Dividing Cells. Molecular Plant, 2011, 4（2）：264–278.
39. Fu, J., Jiang, Q. & Zhang, C., Coordination of Cell Cycle Events by Ran GTPase. Nature Education ,2010, 3(9):32.
40. Fu, J., Jiang, Q. & Zhang, C., Collaboration of Mitotic Kinases in Cell Cycle Control. Nature Education, 2010, 3(9):82.
41. BIAN MingLei, FU JingYan, YAN Y, JIANG Qing, and ZHANG ChuanMao*, Short Exposure to Paclitaxel Induces Multi-polar Spindle Formation and Aneuploidy through Promoting Acentrosomal Pole Assembly, CHINESE SCI BULL, 2010, 53（11）：1322-1329.
42. Xuelong Lu, Yang Shi, Quanlong Lu, Yan Ma, Jia Luo, Qingsong Wang, Jianguo Ji, Qing Jiang and Chuanmao Zhang*, Requirement for lamin B receptor and its regulation by importin β and phosphorylation in nuclear envelope assembly during mitotic exit, J Biol Chem., 2010, 285: 33281–33293.
43. Wenxiang Fu, Wei Tao, Puwei Zheng, Jingyan Fu, Minglei Bian, Qing Jiang, Paul R Clarke and Chuanmao Zhang*, Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. Journal of Cell Science, 2010, 123, 3645-3651.
44. Qinying Liu, Jingying Yu, Xiaolong Zhuo, Qing Jiang and Chuanmao Zhang*， Pericentrin contains five NESs and an NLS essential for its nucleocytoplasmic trafficking during the cell cycle, Cell Research, 2010, 20:948–962.
45. Zhang J, Liu W, Liu J, Xiao W, Liu L, Jiang C, Sun X, Liu P, Zhu Y, Zhang C, Chen Q. G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nat Commun. 2010 Oct 19;1:101. doi: 10.1038/ncomms1099.
46. Qinying Liu, Qing Jiang and Chuanmao Zhang*, A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin. Biochemical and Biophysical Research Communications, 2009, 384: 383-388.
47. Xiaoyan Zhang, Qiang Chen, Jia Feng, Junjie Hou, Fuquan Yang, Junjun Liu, Qing Jiang and Chuanmao Zhang*, Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the γTuRC to the centrosome, Journal of Cell Science, 2009,122, 2240-2251.
48. Jingyan Fu, Minglei Bian, Junjun Liu, Qing Jiang, and Chuanmao Zhang*, A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc. Natl. Acad. Sci. USA (PNAS), 2009, 106 (17): 6939–6944.
49. Fei Lu, Rongfeng Lan, Hongyin Zhang, Qing Jiang, and Chuanmao Zhang*., Geminin is partially localized to centrosome and plays a role in proper centrosome duplication. Biology of the Cell Decision Letter, 2009, 101, 273–285.
50. Yan Ma, Shang Cai, Quanlong Lu, Xuelong Lu, Qing Jiang, Jun Zhou and Chuanmao Zhang*, Inhibition of Deacetylation Impairs Microtubule-kinetochore Attachment through Interfering with Kinetochore Integrity, Centromere Function and Microtubule Behavior. Cellular and Molecular Life Sciences, 2008, 65：3100-3109.
51. Clarke PR and Zhang CM., Spatial and temporal coordination of mitosis by Ran GTPase. Nature Review Molecular Cell Biology, 2008, 9: 467-477.
52. Qiang Chen, Xiaoyan Zhang, Qing Jiang, Paul Clarke, and Chuanmao Zhang*, Cyclin B1 is localized to unattached kinetochores and is required for chromosome alignment during mitosis. Cell Research, 2008, 18: 268-280.
53. Lei Sun , Dengwen Li, Xin Dong , Haiyang Yu , Jin-Tang Dong ,Chuanmao Zhang , Xianyu Lu , Jun Zhou*, Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells. Biochemical Pharmacology, 2008, 75: 1027–1034.
54. Long Zhao, Xinyi Zhao, Tian Tian, Quanlong Lu, Nirma Skrbo-Larssen ,DiWu, Zheng Kuang，Xiaofeng Zheng, Yanchao Han, Shuyan Yang, Chuanmao Zhang, and Anming Meng*, Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular Research, 2008, 80:200-208.
55. Yan Ma, Shang Cai, Quanlong Lv, Xuelong Lv, Quan Zhang, Qing Jiang, Sodmergen，Zhonghe Zhai and Chuanmao Zhang*., Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β. Journal of Cell Science, 2007, 120: 520-530.
56. Jingyan Fu，Minglei Bian，Qing Jiang and Chuanmao Zhang*, Roles of Aurora Kinases in Mitosis and Tumorigenesis. Molecular Cancer Research. 2007, 5(1). 1-10.
57. Xiaofeng Zheng, Xueyu Dai, Yanmei Zhao, Qiang Chen, Fei Lu, Deqiang Yao, Quan Yu, Xinping Liu, Chuanmao Zhang, Xiaocheng Gu, and Ming Luo*, Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc. Natl. Acad. Sci. USA (PNAS), 2007, 104（21）：8809–8814
58. Zhe Liu, Hao Lin, Sheng Ye, Qin-ying Liu, Zhaohui Meng, Chuanmao Zhang, Yongjing Xia, Emanuel Margoliash, Zihe Rao, and Xiang-jun Liu*, Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis. Proc. Natl. Acad. Sci. USA (PNAS), 2006, 103: 8965–8970.
59. Chen Z, Cai S, Jiang Q, Zhang C* & Tang X., Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis. Chinese Science Bulletin., 2005, 50: 229-235
60. Zhigang Lu, Chuanmao Zhang*, and Zhonghe Zhai*, Nucleoplasmin regulates chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. USA (PNAS), 2005, 102: 2778-2783.
61. Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su., The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus. Proc. Natl. Acad. Sci. USA (PNAS) ,2005, 102:303-308.
62. Qing Jiang, Zhigang Lu and Chuanmao Zhang*. Roles of Ran GTPase in the Cell Cycle Regulation coordination. CHINESE SCI BULL, 2004, 49（6）:535-541.
63. Zhigang Lu, Chuanmao Zhang* and Zhonghe Zhai*, LDFF, the large molecular weight DNA fragmentation factor, is responsible for the large molecular weight DNA degradation during apoptosis in Xenopus egg extracts. Cell Research, 2004, 14:134-140.
64. Yang N, Chen ZC, Lu P, Zhang CM (Corresponding Author), Zhai ZH*, Tang XW*. The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts. CHINESE SCI BULL，2003，48 (18): 1912-1918.
65. William J. Moore, Chuanmao Zhang, and Paul R. Clarke*, Targeting of RCC1 to Chromosomes Is Required for Proper Mitotic Spindle Assembly in Human Cells. Current Biology, 2002, 12, 1442–1447.
66. Zhang, C., Goldberg, M., Moor, W., Allen, T. D., and Clarke, P. R.*, Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly. European J. Cell Biol., 2002, 81 (11): 623-633.
67. Zhang, C., Hutchins, JR, Mulhausser, P, Kutay, U., mand Clarke, P. R.*, Role of Importin β in the Control of Nuclear Envelope Assembly by Ran. Current Biology, 2002, 12: 498-502.
68. Clarke, PR and Zhang C., Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? Trends in Cell Biol., 2001,11:366-371.
69. Zhang, C., and Clarke, P. R., The roles of RanGDP and RanGTP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system. Current Biology, 2001, 11:208-212.
70. Zhang, C.*, and Clarke, P. R.*, Chromatin-independent Nuclear Envelope Assembly induced by RanGTPase in Xenopus Egg Extracts. Science, 2000, 288:1429-1432.
71. Zhang, C., Hughes, M., Clarke, P. R.*, Ran-GTP stablises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 1999, 112: 2453-2461.
72. Hughes, M., Zhang, C (Co-first Author), Avis, J. M., Hutchison, C. J, Clarke, P. R.*,The role of the Ran GTPase in nuclear assembly and DNA replication: Characterization of the effects of Ran mutants. Journal of Cell Science, 1998, 111:3017-3026.
73. Nicholas, F., Zhang, C., Hughes, M., Goldberg, M., Clarke, P.*, Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts. Journal of Cell Science, 1997, 110:3019-3030.
74. Zhang, Chuanmao., Gordberg, M. W., Allen, T.D., and Hutchison, C. J.*, Nuclear lamina and nuclear matrix organization in sperm pronuclei assembled in Xenopus egg extract. Journal of Cell Science, 1996, 109: 2275-2286.

I.  本實驗室長期以來主要以細胞生物學、分子生物學和生物化學等為研究手段，在分子水平、細胞和亞細胞水平以及組織和個體水平上，從事幹細胞增殖與分化、細胞周期調控、細胞核結構和動态變化及功能、Ran GTP酶功能調控等方面的研究。實驗材料主要包括：培養細胞，小鼠，非洲爪蟾，果蠅等。

II.  已取得如下主要成績： 

1，發現Ran GTPase 控制核膜裝配(Science, 2000; Curr Biol, 2011; J Cell Sc, 2012）。
2，發現Ran GTPase 控制紡錘體組裝(J Cell Sci, 1999)。 
3，建立了應用相關蛋白質小球和細胞(包括卵細胞)提取物為材料的非細胞體系核膜重建模式(Curr Biol, 2001, 2002; Eur J Cell Biol,2002）。
4，發現核膜物質運輸相關蛋白importin alpha和beta 參與核膜裝配(Curr Biol, 2002；Cell Res，2012)。
5，發現Ran 調控核孔複合體裝配(Eur J Cell Biol, 2002；Cell Res，2012)。
6，發現RCC1在染色體上定位所産生的Ran-GTP梯度是紡錘體正确裝配所需要的(Curr Biol, 2002)。
7，發現Ran GTPase 通過調控核膜物質運輸進而調控DNA 複制(J Cell Sci,1998)。
8，以實驗證明細胞核纖層(Nuclear lamina)對細胞核結構的維持和DNA 複制起重要調控作用(J Cell Sci,1996)。
9，發現Nucleoplasin在非洲爪蟾卵提取物細胞凋亡過程中調控染色質的凝集(PNAS，2005)。

10，發現Aurora A/B, Plk1, Cdk1等激酶綜合調控紡錘體裝配(PNAS，2009，2013；Cell Res, 2008, 2011; J Cell Sci, 2009, 2013a, 2013b)。 

11，發現CDK1, Aurora A/B和TPX2等綜合調控紡錘體裝配的新機制（J Cell Biol, 2015a; J Cell Sci, 2015；J Biol Chem, 2015)。

12, 發現去泛素化酶Ups16和Plk1綜合調控動粒與紡錘體微管的結合及紡錘體裝配的調控機制（J Cell Biol，2015b；CMLS，2017）。

13，發現細胞周期調控因子調控初級纖毛動态變化及其細胞信号轉導功能（J Cell Sci, 2013， 2014；PLoS Biol, 2015; J Biol Chem, 2017a）。

14，發現DNA複制起始調控因子CDC6調控rDNA轉錄的新機制（J Cell SCI，2016）和調控中心體複制的新機制（NatureCommunications，2017）。

15，發現CDK4-Cyclin D1激酶調控細胞周期起始的新機制（J Biol Chem，2017b）。

III.  在研經費主要來源：科技部幹細胞專項；科技部蛋白質機器專項；基金委重點課題；基金委重大國際合作等。

IV.   熱烈歡迎有志從事相關基礎研究的優秀博士後、博士研究生和本科生加盟。