教育經曆:

2001 – 2004, 理學博士 , 生物化學與分子生物學 , 北京協和醫學院
1998 – 2001, 理學碩士 , 生物化學與分子生物學 , 蘭州大學
1994 - 1998, 理學學士 , 生物化學 , 蘭州大學

工作經曆:

2019.06 - 至今， 高級工程師, 實驗動物中心，北京大學
2013.11 - 2019.05, 副研究員 , beat365，北京大學
2008.5 – 2012.11 博士後, 美國麻省總醫院 哈佛醫學院/紐約西奈山醫學院
2004.9 – 2008.4, 助理研究員, 醫學分子生物學國家重點實驗室 中國醫學科學院基礎所

執教課程:

1. 實驗動物使用基礎
2. 實驗室安全--實驗動物安全

      1. 利用基因修飾大、小鼠動物模型研究重要轉錄調控因子在心髒發育以及心血管疾病中的作用與分子機理；
　　2. 動物細胞基因編輯技術改進與大、小鼠基因修飾動物模型平台的優化建立。

1. Yusheng Wei*, Siwu Peng*, Ravi Sachidanandam, Zhidong Tu, Shihong Zhang, Christine Falce, Eric Sobie, Djamel Lebeche, Yong Zhao. Multifaceted roles of miR-1s in repressing the fetal gene program in the heart. Cell Research. 2014, 24(3): 278-292. (#co-first author).
2. Ya-Jun Li*, Yu-Sheng Wei*, Xiang-Hui Fu, De-Long Hao, Zhen Xue, and De-Pei Liu, Chih-Chuan Liang. The apoCIII enhancer regulates both the extensive histone modification and intergenic transcripts of human apoAI/CIII/AIV genes but not apoAV. J Biol Chem. 2008, 283(42):28436-44. ( *co-first author )
3. Jun Gao*, Yusheng Wei*, Yue Huang , Depei Liu, Guang Liu, Min Wu , Lin Wu, Qingjun Zhang, Zhuqin Zhang, Ran Zhang, Chihchuan Liang.The expression of intact and mutant human apolipoprotein AI/CIII/AIV/AV gene cluster in transgenic mice. J Biol Chem. 2005, 280(13): 12559-66. ( *co-first author ).
4. Wei Zheng, Yun-Biao Lu, Shu-Ting Liang, Qing-Jun Zhang, Jing Xu, Zhi-Gang She, Zhu-Qin Zhang, Rui-Feng Yang, Bei-Bei Mao, Zhen Xu, Li Li, De-Long Hao, Jie Lu, Yu-Sheng Wei, Hou-Zao Chen, De-Pei Liu. SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes. Basic Res Cardiol. 2013;108(4):364-9.
5. Shuang Zhou, Hou-Zao Chen, Yan-zhen Wan, Qing-Jun Zhang, Yu-Sheng Wei, Shuai Huang, Jin-Jing Liu, Yun-Biao Lu, Zhu-Qin Zhang, Rui-Feng Yang, Ran Zhang, Hua Cai, De-Pei Liu, Chih-Chuan Liang. . Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res. 2011, 109(6):639-48.
6. Li Li, Hui-Na Zhang, Hou-Zao Chen, Peng Gao, Li-Hua Zhu, Hong-Liang Li, Xiang Lv, Qing-Jun Zhang, Ran Zhang, Zhao Wang, Zhi-Gang She, Ran Zhang, Yu-Sheng Wei, Guan-Hua Du, De-Pei Liu, Chih-Chuan Liang. SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res. 2011, 13;108(10):1180-9.
7. Wei Zhou, Ying Zhang, Yiping Li, Yu-Sheng Wei, Guang Liu, De-Pei Liu, Samuel J Pleasure, Wei Xie, Chunjie Zhao. A transgenic Cre mouse line for the study of cortical and hippocampal development. Genesis. 2010, 48(5):343-50.
8. Ran Zhang, Hou-Zao Chen, Jin-Jing Liu, Yu-Yan Jia, Zhu-Qin Zhang, Rui-Feng Yang, Yuan Zhang, Jing Xu, Yu-Sheng Wei, De-Pei Liu and Chih-Chuan Liang. SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem. 2010, 285(10):7097-110.
9. Zhi-Gang She, Wei Zheng, Yu-Sheng Wei, Hou-Zao Chen, Ai-Bing Wang, Hong-Liang Li, Guang Liu, Ran Zhang, Jin-Jing Liu, William B. Stallcup, Zhongjun Zhou, De-Pei Liu, Chih-Chuan Liang. Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice. Circ Res. 2009, 104(10):1160-8.
10. Qing-jun Zhang, Zhao Wang, Hou-zao Chen, Shuang Zhou, Wei Zheng, Guang Liu, Yu-sheng Wei, Hua Cai, De-pei Liu, Chih-chuan Liang. Endothelium-specific Overexpression of Class III Deacetylase SIRT1 Decreases Atherosclerosis in ApoE Deficient Mice. Cardiovasc Res. 2008, 80(2):191-9.
11. Hong-Liang Li, Ming-Lei Zhuo, Dong Wang, Ai-Bing Wang, Li-Hong Sun, Qinglin Yang, Yue Huang, Yu-Sheng Wei, De-Pei Liu,Chih-Chuan Liang. Overexpression of A20 Improves Left Ventricular Performance and Reduces Compensatory Hypertrophy after Myocardial Infarction. Circulation, 2007, 115(14):1885-94