個人介紹:

陳雪梅教授1988年獲得北京大學生物學學士學位，1995年獲得美國康奈爾大學生物化學博士學位，随後在加州理工學院進行博士後研究。她于1999年在羅格斯大學瓦克斯曼研究所擔任助理教授，于2005年晉升為副教授，并獲得羅格斯大學董事會學術卓越研究獎。她于2005年轉至加州大學河濱分校，任副教授，2009年晉升為正教授，2013年晉升為講席教授。自2023年2月起，任beat365官方网站講席教授、院長。2006年獲美國植物生物學家協會頒發的查爾斯·阿爾伯特·舒爾獎，2011年當選為AAAS研究員，2012年至2018年任HHMI-GBMF研究員。2013年當選為美國國家科學院院士。2018年獲得了南加州華裔科學家和工程師協會的成就獎。2023年獲美國植物生物學家協會頒發的Martin Gibbs Medal. 2024年獲得求是基金會的傑出科學家獎。她的研究方向是花的發育、植物小RNA和RNA修飾。

教育經曆:

1984-1988 學士，北京大學
1989-1995 博士，美國康奈爾大學

工作經曆:

2023-　　院長，beat365官方网站
2023-　　特聘教授，北京大學
2013-2023 特聘教授，加州大學河濱分校
2009-2013 教授，加州大學河濱分校
2005-2009 副教授，加州大學河濱分校
1999-2005 助理教授，美國羅格斯大學 （新澤西州立大學）
1995-1998 博士後，美國加州理工學院

社會服務工作:

Keystone symposia Scientific Advisory Board， 2022-2025
Scientific Advisory Board, Max Planck Institute, Tubingen, 2023-2026
Gibbs Medal Committee, American Association of Plant Biologists, 2025
國家自然科學基金委員會第二屆咨詢委員會委員，2024

雜志任職:

Editorial Board member of Developmental Cell, 12/2024 - present

Senior editor, The Plant Cell, 04/2020 – present

Consulting Editor of PLOS Genetics, January 2016 - present

Editorial Board member of National Science Review 2015 – present

Editorial Board member of Molecular Plant, December 2014 – present

Editorial Board member of Science in China, 2014 - present

      早期研究植物花形态建成的基因調控機制，發現與RNA代謝相關的蛋白參與花器官分化。進而發現其中某些蛋白參與小RNA 代謝與功能。之後主要研究小RNA的生物合成， 降解，及作用機制。
目前的主要研究方向之一為小RNA的細胞間運輸機制及作為信号分子調控植物響應溫度變化的機制。第二個主要研究方向為RNA的非典型加帽修飾， 比如NAD， FAD， dpCoA 帽子的加入，去除機制及分子功能。第三個研究方向為葉綠體發育， 基因表達， 及RNA 修飾。

Jing Li, Brandon Le, Ye Xu, Suikang Wang, Lei Gao, Beixin Mo, Lin Liu*, Xuemei Chen*. (2025). ALTERED MERISTEM PROGRAM1 impairs RNA silencing through repressing the biogenesis of inverted repeats-derived siRNAs in Arabidopsis. Plant Cell, DOI:/10.1093/plcell/koae293.

Runlai Hang*,Hao Li, Runyu Wang, Hao Hu, Meng Chen, Chenjiang You* and Xuemei Chen*. (2024). HOT3/eIF5B1 confers Kozak motif-dependent translational control of photosynthesis-associated nuclear genes for chloroplast biogenesis. Nature Comm. 15, 9878.

Xufeng Wang, Dongli Yu, Jiancheng Yu, Hao Hu, Runlai Hang, Zachary Amador, Qi Chen, Jijie Chai, and Xuemei Chen*. (2024). Toll/interleukin-1 receptor (TIR) domain-containing proteins exhibit deNAMing activity towards NAD-capped RNAs. Nature Comm. 15: 2261. 10.1038/s41467-024-46499-y

Qing Sang, Lusheng Fan, Tianxiang Liu, YongjianQiu, Juan Du, Beixin Mo, Meng Chen*, and Xuemei Chen*. (2023). MicroRNA156 conditions auxin sensitivity to enable growth plasticity in response to environmental changes in Arabidopsis. Nature Comm. 14, 1449.

Yuan Wang, Brandon H. Le, Jianqiang Wang, Chenjiang You, Yonghui Zhao, Mary Galli, Ye Xu, Andrea Gallavotti, Thomas Eulgem, Beixin Mo*, and Xuemei Chen*. (2022). A novel factor that recruits and excludes Pol IV-mediated DNA methylation in a site-specific manner. Science Advances 8, DOI: 10.1126/sciadv.adc9454.

Lusheng Fan, Cui Zhang, Yong Zhang, Ethan Stewart, Jakub Jez, Keiji Nakajima, and Xuemei Chen*. (2022). Microtubules promote the non-cell autonomous action of microRNAs by inhibiting their cytoplasmic loading onto ARGONAUTE1 in Arabidopsis. Dev. Cell. 57, 995-1008.

Xuemei Chen* and Oded Rechavi*. (2021). Plant and animal small RNA communications between cells and organisms. Nature Rev. Mol. Cell Biol. 23, 85–203.

Hao Hu, Nora Flynn, Hailei Zhang, Chenjiang You, Runlai Hang, Xufeng Wang, Huan Zhong, Zhulong Chan, Yiji Xia*, and Xuemei Chen*. (2021). SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts. PNAS 118 (13) e2025595118.

Yuan Wang, Shaofang Li, Yonghui Zhao, Chenjiang You, Brandon Le, Zhizhong Gong, Beixin Mo, Yiji Xia and Xuemei Chen*. (2019). NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated. PNAS 116, 12094-12102

Zhenxia Su, Lihua Zhao, Yuanyuan Zhao, Shaofang Li, So Youn Won, Hanyang Cai, Lulu Wang, Zhenfang Li, Yuan Qin*, and Xuemei Chen*. (2017). The THO complex non-cell autonomously represses female germline specification through the TAS3-ARF3 module. Current Biology 27, 1597–1609.

Yu Yu, Lijuan Ji, Brandon Le, Jixian Zhai, Jiayi Chen, Elizabeth Luscher, Lei Gao, Chunyan Liu, Xiaofeng Cao, Beixin Mo, Jinbiao Ma, Blake C. Meyers, and Xuemei Chen*. (2017). ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biology 15(2): e2001272.

Shengben Li, Lin Liu, Xiaohong Zhuang, Yu Yu, Xigang Liu, Xia Cui, Lijuan Ji, Zhiqiang Pan, Xiaofeng Cao, Beixin Mo, Fuchun Zhang, Natasha Raikhel, Liwen Jiang, and Xuemei Chen*. (2013). microRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell 153, 562-574.

Yuanyuan Zhao, Yu Yu, Jixian Zhai, Vanitharani Ramachandran, Thanh Theresa Dinh, Blake C. Meyers, Beixin Mo*, and Xuemei Chen*. (2012). The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation. Current Biology 22, 689-694.

Vanitharani Ramachandran and Xuemei Chen*. (2008). Degradation of microRNAs by a family of exoribonucleases in Arabidopsis. Science 321, 1490-1492.

Junjie Li, Zhiyong Yang, Bin Yu, Jun Liu, and Xuemei Chen*. (2005). Methylation protects miRNAs and siRNAs from a 3’ end uridylation activity in Arabidopsis. Current Biology 15, 1501-1507.

Bin Yu, Zhiyong Yang, Junjie Li, Svetlana Minakhina, Maocheng Yang, Richard W. Padgett, Ruth Steward, and Xuemei Chen*. (2005). Methylation as a crucial step in plant microRNA biogenesis. Science 307, 932-935.

Xuemei Chen*. (2004). A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Science 303, 2022-2025.