個人介紹:

2003年師從趙進東院士于beat365官方网站獲得生物科學學士學位，2004年至2009年師從諾貝爾獎得主Michael Brown和Joseph Goldstein教授于美國得克薩斯大學西南醫學中心獲得生物醫學博士學位，2009年至2015年師從Marc Tessier-Lavigne教授先後在美國基因泰克公司和洛克菲勒大學從事博士後研究，2015年入職beat365官方网站擔任博士生導師。

教育經曆:

2004-2009，理學博士，美國得克薩斯大學西南醫學中心
1999-2003，理學學士，beat365官方网站

工作經曆:

2024-至今，名譽教授，北京協和醫院
2023-至今，雙聘教授，北京大學第三醫院
2022-至今，博雅特聘教授，北京大學
2020-2023，合作研究員，北京腦科學與類腦研究中心
2019-2024，合作研究員，深圳灣實驗室
2017-2022，博雅青年學者，北京大學
2015-至今，研究員，北京大學麥戈文腦科學研究所
2015-至今，研究員，北京大學生命科學聯合中心
2015-至今，博士生導師，beat365官方网站
2011-2015，博士後，美國洛克菲勒大學（The Rockefeller University）
2009-2011，博士後，美國基因泰克公司（Genentech Inc.）

榮譽獎勵:

2021，中國神經科學重大進展
2020，北京大學優秀博士論文指導教師
2018，北京大學優秀班主任
2016，“求是”傑出青年學者獎
2015，Tri-Institutional Breakout Prize

執教課程:

春季學期（第二學期）：
《免疫學》，本科課程，34學時
《神經病理學》，本科課程，34學時

      整合臨床資源、動物疾病模型、先進成像技術、多組學分析等跨學科手段，緻力于生物醫學前沿交叉方向，探索神經系統、免疫系統、代謝系統、循環系統等互作調控，在分子、細胞、器官、機體等不同層面開拓神經免疫（neuroimmunology）、神經代謝（neurometabolism）、腫瘤神經生物學（cancer neuroscience）等創新概念和視角，鑒定并驗證神經系統疾病、代謝疾病、惡性腫瘤等重大人類疾病的全新診療策略和藥物靶點。獲得國家高層次青年人才項目、優秀青年科學基金、傑出青年科學基金、原創探索計劃、專項項目、重點研發計劃等國家級科研項目支持，并與生物制藥産業建立合作轉化。主要研究方向包括：
1. 腫瘤的神經免疫互作；
2. 代謝疾病及并發症；
3. 免疫紊亂和自免疫疾病；
4. 神經退行性疾病和神經炎症。

Publications since the current position:
1. Representative Publications (# corresponding author):
(1) Gong X, Dai X, Cheng W, Li B, Liu J, Chen H, Wu M#, Yang J#, Liu B#. Targeted High-resolution 3D Imaging of Tumor Vasculatures at Different Stages Using Far-red AIE Nanoparticles Compatible with Tissue-Clearing. Advanced Materials. 2025 (in press)
(2) Li T, Wang G, Zhao H, Liu F, Deng Z, Chen D, Zhou X, Cao Y, Fu W, Zhang H#, Yang J#. Estrogen Receptor 1 Signaling in Hepatic Stellate Cells Designates Resistance to Liver Fibrosis. Cell Discovery. 2025 (in press)
(3) Huang Y, Zhou X, Liu J, Cao Y#, Fu W#, Yang J#. Emerging Neuroimmune Mechanisms in Cancer Neuroscience. Cancer Letters. 2025 Mar 1;612:217492.
(4) Chen H, Zhou X, Liu T, Liu J, Wu D, Xu X, Ma S, Qiang G, Chen J, Cao Y#, Fu W#, Yang J#. Postprandial Parasympathetic Signals Promote Lung Type 2 Immunity. Neuron. 2025 Jan 12:S0896-6273(24)00919-X.
(5) Zhao Y, Huang Y, Deng Z, Cao Y#, Yang J#. Inflammatory Signatures of Microglia in Hypercortisolemia-Related Depression. Cell Insight. 2025 Apr;4(2):100222.
(6) Zhao J, Wu D, Liu J, Zhang Y, Li C, Zhao W, Cao P, Wu S, Li M, Li W, Liu Y, Huang Y, Cao Y, Sun Y, Yang E, Ji N#, Yang J#, Chen J#. Disease-Specific Suppressive Granulocytes Participate in Glioma Progression. Cell Reports. 2024 Dec;43(12):115014.
(7) Zhao Y, Huang Y, Cao Y, Yang J#. Astrocyte-Mediated Neuroinflammation in Neurological Conditions. Biomolecules. 2024 Sep;14(10):1204.
(8) Gong X, Zhuang J, Chong K, Xu Q, Ling X, Cao L, Wu M#, Yang J#, Liu B#. Far-Red Aggregation-Induced Emission Hydrogel-Reinforced Tissue Clearing for 3D Vasculature Imaging of Whole Lung and Whole Tumor. Advanced Materials. 2024 Aug;36(35):2402853.
(9) Xu Q, Cao Y, Kong F, Liu J, Chen X, Zhao Y, Lai CH, Zhou X, Hu H, Fu W, Chen J, Yang J#. Multiple Cancer Cell Types Release LIF and Gal3 to Hijack Neural Signals. Cell Research. 2024 May;34(5):345-354.
(10) Gong X, Chong K, Liu J, Cheng W, Yang J#, Liu B#. AIENP-Reinforced DISCO Method for Whole-Tissue Three-Dimensional Reconstruction of Pulmonary Capillaries. Advanced Functional Materials. 2024 Mar;34(13):2312176.
(11) Zhang M, Liu T, Yang J#. Skin neuropathy and immunomodulation in diseases. Fundamental Research. 2024 Mar;4(2):218-225.
(12) Liu J, Li Z, Li M, Du W, Baumeister W, Yang J#, Guo Q#. Vimentin regulates nuclear segmentation in neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 2023 Nov 28;120(48):e2307389120.
(13) Liu T, Liu J, Chen H, Zhou X, Fu W, Cao Y, Yang J#. Cannabinoid receptor 2 signal promotes type 2 immunity in the lung. Cell Insight. 2023 Oct 6;2(5):100124.
(14) Cao Y, Chen H, Yang J#. Neuroanatomy of lymphoid organs: Lessons learned from whole‐tissue imaging studies. European Journal of Immunology. 2023 Oct;53(10):e2250136.
(15) Cao Y, Liu T, Zhou X, Fu W, Li J, Yang J#. 3D anatomy of autonomic innervations in immune organs of a non-human primate and the human. Fundamental Research. 2023 Mar;3(2):249-256.
(16) Yang J#, Yaron A, Liu K. Editorial: Neuroimmune interactions in peripheral neuropathy. Frontiers in Molecular Neuroscience. 2022 May;15:929081.
(17) Liu C, Yang J#. Enteric glial cells in immunological disorders of the gut. Frontiers in Cellular Neuroscience. 2022 Apr;16:895871.
(18) Cao Y, Wang Y, Yang J#. NAD+-dependent mechanism of pathological axon degeneration. Cell Insight. 2022 Apr;1(2):100019.
(19) Sun Y, Wang Q, Wang Y, Ren W, Cao Y, Li J, Zhou X, Fu W, Yang J#. Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon. Protein Cell. 2021 Aug;12(8):621-638.
(20) Liu K, Yang L, Wang G, Liu J, Zhao X, Wang Y, Li J, Yang J#. Metabolic stress drives sympathetic neuropathy within the liver. Cell Metabolism. 2021 Mar 2;33(3):666-675.e4.
(21) Jiang Y, Liu T, Lee CH, Chang Q, Yang J#, Zhang Z#. The NAD(+)-mediated self-inhibition mechanism of pro-neurodegenerative SARM1. Nature. 2020 Dec;588(7839):658-663.
(22) Liu T, Yang L, Han X, Ding X, Li J, Yang J#. Local sympathetic innervations modulate the lung innate immune responses. Science Advances. 2020 May 13;6(20):eaay1497.
(23) Wang Q, Liu K, Yang L, Wang H, Yang J#. BoneClear: whole-tissue immunolabeling of the intact mouse bones for 3D imaging of neural anatomy and pathology. Cell Research. 2019 Oct;29(10):870-872.
(24) Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, Wang Q, Yang J#. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Reports. 2019 Jun 25;27(13):3799-3807.e3.
(25) Zhou N, Liu K, Sun Y, Cao Y, Yang J#. Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition. Protein Cell. 2019 Feb;10(2):87-103.
(26) Zhou N, Yang J#. Molecular Mechanism of Wallerian Degeneration. Chinese Bulletin of Life Sciences. 2017 Mar; 29(3): 245-250.

2. Additional Publications:
(1) Liu T, Wang H, Kutsovsky DY, Iskols M, Chen H, Ohn CYJ, Patel N, Yang J, Simon DJ. An axon-T cell feedback loop enhances inflammation and axon degeneration. Cell Reports. 2024 Feb 27;43(2):113721.
(2) Yang L, Wang X, Yu XX, Yang L, Zhou BC, Yang J, Xu CR. The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms. Developmental Cell. 2023 Sep 25;58(18):1688-1700.e6.
(3) Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z. Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discovery. 2022 Dec 28;8(1):141.
(4) Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z. Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8. Nature Communications. 2022 Aug 25;13(1):4988.
(5) Hu H, Cui YW, Yang J, Cao Y. Loss of the sympathetic signal produces sterile inflammation of the prostate. Frontiers in Molecular Neuroscience. 2022 May;15:855376.
(6) Li X, Qi L, Yang D, Hao S, Zhang F, Zhu X, Sun Y, Chen C, Ye J, Yang J, Zhao L, Altmann DM, Cao S, Wang H, Wei B. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nature Neuroscience. 2022 May;25(5):577-587.
(7) Qian K, Liu J, Cao Y, Yang J, Qiu S. Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice. Molecular Brain. 2021 Apr 19;14(1):71.
(8) Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology. Nature. 2021 Mar;591(7850):431-437.
(9) Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y. Mutation in ε-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice. Neuroscience Bulletin. 2021 Mar;37(3):311-322.
(10) Simon DJ, Pitts J, Hertz NT, Yang J, Yamagishi Y, Olsen O, Tešić Mark M, Molina H, Tessier-Lavigne M. Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling. Cell. 2016 Feb 25;164(5):1031-45.

3. Book Chapters:
(1) Cao Y, Yang J. Mechanisms of Pathological Axonal Degeneration. In: Tran T.S. and Yaron A.(eds) Wiring the Nervous System, 2024 Jan;215-250. River Publishers, Gistrup, Denmark.
(2) Cao Y, Yang J. Whole-Tissue Immunolabeling and 3D Fluorescence Imaging to Visualize Axon Degeneration in the Intact, Unsectioned Mouse Tissues. In: Babetto E.(eds) Methods in Molecular Biology, 2020 Jun 11;2143:223-232. Humana, New York, NY.
(3) Wang F, Yang J, He Z. Axon maintenance and degeneration. In: Rubenstein J., Rakic P., Chen B., Kwan K.Y., Kolodkin A., and Anton E.(eds) Comprehensive Developmental Neuroscience (2nd Edition), 2020 Jun 5;217-230. Academic Press, Cambridge, MA.

Publications before the current position:
(1) Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15;160(1-2):161-76.
(2) Renier N, Wu Z, Simon DJ, Yang J, Ariel P, Tessier-Lavigne M. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.
(3) Yang J*, Weimer RM*, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M. Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89. (* contributed equally)
(4) Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 5;110(10):4039-44.
(5) Simon DJ, Weimer RM, McLaughlin T, Kallop D, Stanger K, Yang J, O'Leary DD, Hannoush RN, Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. Journal of Neuroscience. 2012 Dec 5;32(49):17540-53.
(6) Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, Freeman MR. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27;337(6093):481-4.
(7) Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. American Journal of Physiology-Endocrinology and Metabolism. 2009 Jul;297(1):E134-41. (* contributed equally)
(8) Yang J*, Zhao TJ*, Goldstein JL, Brown MS. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 5;105(31):10750-5. (* contributed equally)
(9) Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008 Feb 8;132(3):387-96.
(10) Yang J, Dong C, Huang X, Zhao J. Sulfonation of polyvinylidene difluoride resin and its application in extraction of restriction enzymes from DNA digestion solutions. Analytical Biochemistry. 2003 Nov 1;322(1):99-103.