教育經曆:

1993 - 1997 , 理學博士 , 神經化學和神經毒理學 , 瑞典斯德哥爾摩大學 (Stockholm University, Sweden)
1979 - 1983 , 理學學士 , 生理學 , 北京大學

工作經曆:

2007 - 至今 , 教授 , beat365官方网站
1997 - 2007 , 副教授 , beat365官方网站
1988 - 1993 , 講師 , beat365官方网站

榮譽獎勵:

北京市教育教學成果一等獎 , 2008
國家級教學成果一等獎 , 2005
北京市教育教學成果一等獎 , 2004

執教課程:

生理學實驗 , 主持人、主講 , 北京大學 , 春季 2005-
人類生物學導論 , 主講 , 北京大學 , 春季 2002-
生理學 , 主講 , 北京大學 , 春季 1998-

      缺血性腦卒中是危害人類生命健康的重大疾病。在全腦缺血或局部缺血的核心區，胞外谷氨酸濃度可達到100-300mM。谷氨酸的積累造成谷氨酸受體的過度激活，胞内鈣離子超載，并引發神經元的凋亡及壞死。本實驗室的興趣在于利用電生理學和激光共聚焦成像技術、結合分子生物學等實驗方法，研究腦缺血損傷過程中神經元鈣穩态的調控機制、神經元與膠質細胞相互作用機制。另一方面，因冬眠動物達烏爾黃鼠具有耐受低溫和低氧環境的特性，以及近期我們證實黃鼠能夠一定程度抵抗心髒停跳導緻的腦缺血損傷，本實驗室希望從神經元及膠質細胞入手深入研究其缺血耐受的神經機制。

1.Zhao YZ, Wei J, Song KX, Zhou C*, Chai Z*. Glutamate-aspartate transporter 1 attenuates oxygen-glucose deprivation-induced injury by promoting glutamate metabolism in primary cortical neurons. Journal of cellular physiology, 2022.
2.Ma YT, Xie HD, Du XM, Wang LP, Jin XQ, Zhang QQ, Han YW, Sun SC, Wang LT, Li X, et al. In vivo chemical reprogramming of astrocytes into neurons. Cell discovery, 2021, 7(1).
3.Su ZJ, Wang XY, Zhou C*, Chai Z*. Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity. Journal of neurochemistry, 2020, 153(5): 617-630.
4.Zhu MY, Zhang DL, Zhou C*, Chai Z*. Mild acidosis protects neurons during oxygen-glucose deprivation by reducing loss of mitochondrial respiration[J]. ACS chemical neuroscience, 2019.
5.Li X, Liu D, Ma Y, et al. Direct reprogramming of fibroblasts via a chemically induced XEN-like state[J]. Cell stem cell, 2017, 21(2): 264-273. e7.
6.Guo Y., Su, ZJ., Chen, YK, & Chai Z*. Brain‐derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons[J]. Journal of neurochemistry, 2017, 142(2): 260-271.
7.Li X, Zuo X, Jing J, et al. Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons[J]. Cell stem cell, 2015, 17(2): 195-203.
8.Zhao JJ, Gao S, Jing JZ, Zhu MY, Zhou C, Chai Z* , Increased Na+/Ca2+ exchanger activity promotes resistance to excitotoxicity in cortical neurons of the ground squirrel (a Hibernator) , PLoS One , 2014 , 9(11): e113594
9.He JQ, Shi WK, Guo Y, Chai Z* , ERp57 modulates mitochondrial calcium uptake through the MCU , FEBS Lett , 2014 , 588: 2087-2094
10.Dong QP, He JQ, Chai Z* , Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia , Neurobiol Dis , 2013 , 58: 68-75
11.Cui J, Wang YF, Dong QP, Wu SM, Xiao XZ, Hu JY, Chai Z*, Zhang Y* , Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70 , J Neurosci , 2011 , 31: 16227-16240
12.Li XC, Wei L, Zhang GQ, Bai ZL, Hu YY, Zhou Z, Bai S, Chai Z, Lakatta EG, Hao XM, Wang SQ* , Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis , PLoS One , 2011 , 6: e24787 (1-9)
13.Zhou C, Qi C, Zhao JJ, Wang F, Zhang WW, Li C, Jing JZ, Kang XJ, Chai Z* , Interleukin-1β inhibits voltage-gated sodium currents in a time- and dose-dependent manner in cortical neurons , Neurochem Res , 2011 , 36: 1116-1123
14.Sun BN, Lv B, Dong QP, Wang SQ, Chai Z* , Watching moving images specifically promotes development of medial area of secondary visual cortex in rat , Dev Neurobiol , 2009 , 69: 558-567
15.Tang AH, Chai Z, Wang SQ* , Dark rearing alters the short-term synaptic plasticity in visual cortex , Neurosci Lett , 2007 , 206: 799-806
16.Zhou C, Ye HH, Wang SQ, Chai Z* , Interleukin-1β regulation of N-type Ca2+ channels in cortical neurons , Neurosci Lett , 2006 , 403: 181-185
17.Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ, Chai Z* , Interleukin-1β downregulates the L-Type Ca2+ channel activity by depressing the expression of channel protein in cortical neurons , J Cell Physiol , 2006 , 206: 799-806.
18.Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ* , Temperature dependence and thermodynamic properties of Ca sparks in rat cardiomyocytes. , Biophys J , 2005 , 89: 2533-2541
19.Alheim K, Chai Z, Fantuzzi G, Hasanvan H, Di Santo E, Ghezzi P, Dinarello CA, Bartfai T* , Hyperresponsive febrile reactions to IL-1β in IL-1β deficient mice; comparison with cytokine mRNA and protein levels. , Proc Natl Acad Sci USA , 1997 , 94: 2681-2686
20.Loudkvist J, Chai Z, Teheranian R, Hasanvan H, Bartfai T, Jenck F, Widmer U, Moreau JL , A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity , Eur. J. Pharmacol. , 1996 , 309: 195-200
21.Chai Z, Alheim K, Lundkvist J, Gatti S, Bartfai T* , Subchromic glucocorticoid pretreatment reversibly attenuates IL-1β induced fever in rats; IL-6 mRNA is elevated while IL-1α and IL-1β mRNAs are suppressed, in the CNS , Cytokine , 1996 , 8: 227-237
22.Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T* , Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: a study on IL-6-deficient mice. , J Exp Med , 1996 , 183: 311-316