教育經曆:

1986 - 1989 , 理學博士 , 植物科學系 , 美國康奈爾大學
1978 - 1982 , 理學學士 , 農學系 , 浙江農業大學

工作經曆:

2002 - 2017 , 主任 , 蛋白質與植物基因研究國家重點實驗室
1994 - 至今 , 教授 , beat365官方网站
1992 - 1994 , 副教授 , beat365官方网站

社會服務工作:

1. 2013 - 至今 , 主任 , 教育部大學生物學課程教學指導委員會
2. 2013 - 至今 , 技術副總師 , 轉基因生物新品種培育重大專項總體組
3. 2008 - 至今 , 副理事長 , 中國植物學會
4. 2002 - 至今 , 委員 , 農業部國家轉基因生物安全委員會

榮譽獎勵:

何梁何利科學與技術進步獎 , 2012
國家自然科學二等獎 , 2011
國家級教學成果獎二等獎 , 2009
教育部自然科學一等獎 , 2008
教育部科技進步二等獎 , 2000
中國國家圖書提名獎、中國國家科技圖書獎 , 1999

會議發言與組織:

1. 棉花A、D基因組數據分析、基因組演化及基因功能研究,中國植物生理與植物分子生物學學會第十一次會員代表大會暨全國學術年會，貴州貴陽 , 2014.8.5
2. 棉花A、D亞基因組數據分析與前景展望,2013中國作物學會學術年會，鄭州 , 2013.10.20
3. 棉花不同亞基因組數據比較、功能與演化分析,中國植物學會第十五屆會員代表大會暨80周年學術年會，南昌 , 2013.10.13
4. 棉花基因組研究進展,2013年全國植物生物學大會，南京 , 2013.10.8
5. Phylogenetic and biochemical insight of the diploid cotton Gossypium raimondii genome,10th International Conference on the Frontiers of Plant Biology: Development and Environment，安徽黃山 , 2012.11.4
6. Ethylene-regulated pectin biosynthesis is important for the elongation growth of cotton fiber and Arabidopsis root-hair,CSHA/ISSCR Stem Cells Meeting, 蘇州 , 2010.10.24
7. Comparative proteomics reveals important biochemical pathways during cotton fiber elongation,2010年國際棉花基因組研究大會，澳大利亞 , 2010.9.27
8. Insights to the regulatory mechanisms of the transcription factor WUS1,第9屆世界植物分子生物學大會（IPMB）“Symposium: Transcription Factors”，美國密蘇裡州ST LOUIS市 , 2009.10.26
9. 乙烯合成與棉纖維細胞伸長機制研究,遺傳學會植物遺傳和基因組學專業委員會2009年學術研讨會 ，山東泰安 , 2009.9.26
10. 運用功能基因組學方法研究棉纖維細胞伸長機制,第十屆全國植物生理學代表大會，開封 , 2009.8.15
11. Mutation in the Arabidopsis BARD1 BRCT Domain Releases WUSCHEL Expression from the Organizing Center,第九屆全國植物基因組學大會，廣州 , 2008.8.17

雜志編輯:

常務副主編 , 《中國科學：生命科學》（中文版） , 2012 - 至今
Editorial Board Member , 《Molecular Plant》 , 2008 - 至今
編委 , 《生物化學與生物物理學報》 , 2008 - 至今
副主編 , 《遺傳學報》 , 2004 - 至今
特邀編委 , 《科學通報》 , 2004 - 至今

執教課程:

基礎分子生物學 , 主持/主講 , 北京大學 

      基本情況
　　朱玉賢，中國科學院院士，北京大學教授，博士生導師，蛋白質與植物基因研究國家重點實驗室主任。1989年12月在美國康奈爾大學植物科學系獲得博士學位，并去華盛頓大學生物系做博士後。91年6月回國後一直在beat365官方网站工作。97年9月至98年12月去美國加州伯克利大學做訪問教授。現為中國植物學會副理事長，中國生物工程學會理事，農業生物技術專業委員會副主任；《遺傳學報》副主編，《科學通報》特邀編輯，植物分子遺傳國家重點實驗室、農作物基因組學國家重點實驗室學術委員會委員，教育部科學技術委員會生命科學學部委員。1997年獲得國家自然科學基金委“國家傑出青年科學基金”資助，2003年成為國家自然科學基金委“創新團隊”學術帶頭人。培養博士後3名、博士13名、碩士15名。
主要研究方向
　　棉纖維細胞伸長機制、植物激素的作用機制、基因表達調控機制
主要研究成果：
1、棉花纖維發育早期特異性表達基因的大規模分離與克隆
　　首次利用抑制性減法雜交技術在國際上展開了大規模棉纖維中差異表達基因的克隆分離工作，在國際棉花界産生了廣泛的影響。建成了具有國際領先水平的大型高通量陸地棉cDNA芯片，發現植物激素乙烯生物合成途徑在棉花纖維細胞伸長過程中的主導作用。發現超長鍊脂肪酸（VLCFA）參與植物激素信号轉導，在轉錄水平上調控乙烯合成關鍵酶基因ACO的活性。發現受乙烯和超長鍊脂肪酸調控的果膠多糖生物合成是棉纖維細胞初生壁合成和細胞伸長的限速步驟，是世界上第一個在功能基因組學水平證實植物激素乙烯對超常伸長細胞，包括棉纖維和植物根毛等具有正向調節作用的課題組，為調控棉纖維伸長、提高纖維品質提供了重要的理論依據。2008年獲得教育部自然科學一等獎，2011年獲得國家自然科學二等獎。
2、拟南芥轉錄調控因子家族基因的克隆與研究
　　研究拟南芥乳腺癌抑制因子同源基因BARD1突變體，發現缺失BARD1基因時拟南芥幹細胞決定因子WUS的表達從頂端的組織中心轉移到外表層細胞，導緻拟南芥頂端分生組織分化進程受阻。BARD1基因在拟南芥根尖與WOX5相互作用，控制植物向地性生長和根尖分生組織細胞分化。
　　克隆了146個AP2/EREBP轉錄調控因子家族基因（該家族最多可能有147個基因），并進行了大規模基因表達譜分析，找到了一批可能參與調控各種生理過程的受不同環境條件或處理誘導表達的轉錄調控因子基因。通過對拟南芥ATH1基因芯片數據的分析, 鑒定了一個受幹旱脅迫高水平誘導的cDNA片段, 并用RACE方法獲得了其全長cDNA。PCR及定量實時PCR分析表明, 該基因在經幹旱、紫外線照射、脫落酸、高鹽以及水楊酸等脅迫條件處理後表達量均有顯著提高, 特别是幹旱處理後短時間内表達量迅速提高，3 h後即提高到對照樣品的430多倍。通過多序列比對和系統進化分析,将該基因歸于DREB亞家族。由于該基因編碼蛋白含有典型的AP2/EREBP DNA結合結構域，并在N端有一段富含谷氨酰氨殘基的區域，所以将它命名為QRAP2 (Glutamine-rich AP2)。凝膠阻滞實驗結果顯示, QRAP2蛋白能夠特異結合DRE順式元件序列但不能與mDRE和GCC等非相關元件結合。酵母單雜交實驗表明，QRAP2蛋白全長序列或其N端112個氨基酸與GAL4 DNA結合結構域形成的融合蛋白表現出轉錄激活功能，而其C端135個氨基酸與GAL4 DNA結合結構域的融合蛋白則沒有表現出轉錄激活活性。現有資料的分析表明，QRAP2是AP2/EREBP轉錄因子家族的新成員，可能在幹旱脅迫條件下參與激活相關下遊基因的表達。還研究了TINY2等多個轉錄因子的表達特性。正在通過拟南芥缺失突變體對參與植物抗性反應及植物激素ABA信号轉導相關基因進行系統性功能研究。
3、論文論著
　　已發表經同行評審的科研論文106篇，其中被SCI收錄96篇（通訊作者或第一作者的SCI論文70篇），包括2篇Nature Genetics，3篇植物科學國際最前沿刊物Plant Cell，1篇美國科學院院報，1篇Mol. Cell. Proteomics，2篇 CURR OPIN PLANT BIOL。總影響因子超過392，篇均影響因子相當于世界植物科學排名10％的刊物。論文共被SCI引用1400多次，其中他引1200多次，高水平學術刊物如Nature及其系列刊物，Science，PNAS，Plant Cell及年評、年鑒等引用160多次。所主編的《現代分子生物學》一書從1997年出版至今17年來（四版）已發行超過40萬冊，成為我國高等學校生物學專業本科生分子生物學最主要的教材，在青年學生中産生了廣泛影響。

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Li WW, Chen X, Yu JN, Zhu YX (2024) Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance. Sci. China Life Sci. 67 (6), 1266-1279.
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Eun-Ji Kim, Zhang Ch, Guo BY, Thomas Eekhout, Anaxi Houbaert, Jos R. Wendrich, Niels Vandamme, Manish Tiwari, Claire Simon-­Vezo, Isabelle Vanhoutte, Yvan Saeys, Wang K, Zhu YX, Bert De Rybel and Eugenia Russinova (2023) Cell type–specific attenuation of brassinosteroid signaling precedes stomatal asymmetric cell division. PNAS, 120, e2303758120.
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Li Yang, Xi W, Hao JF, Zhang L, Wen XP, Wu ZG and Zhu YX (2023) A Novel Tandem Zinc Finger Protein in Gossypium hirsutum, GhTZF2, Interacts with GhMORF8 to Regulate Cotton Fiber Cell Development. Agronomy-Basel, 13, 519.
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Zhang, L., Yang, Y., Mu, C., Liu, M., Ishida, T., Sawa, S., Zhu, Y., and Pi, L. (2022) Control of Root Stem Cell Differentiation and Lateral Root Emergence by CLE16/17 Peptides in Arabidopsis. Front Plant Sci 13, 869888.
Gao J, Huang G, Chen X and Zhu YX (2022) PROTEIN S-ACYL TRANSFERASE 13/16 (PAT13/PAT16) modulate disease resistance by S-acylation of the NB-LRR protein R5L1 in Arabidopsis. Journal of Integrative Plant Biology, 64 (9), 1789-1802.
Wu ZG, Xi W, Han ZX, Wu YH, Guan YZ and Zhu YX (2022) Genome-Wide Comparative Analysis of Transposable Elements by Matrix-TE Method Revealed Indica and Japonica Rice Evolution. Agronomy-Basel, 12 (7), 1490.
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Liu W, Sun J, Li J, Liu C, Si F, Yan B, Wang Z, Song X, Yang Y, Zhu YX and Cao XF (2022). Reproductive tissue-specific translatome of a rice thermo-sensitive genic male sterile line. J. Genet. Genomics. 49(7) , 624-635.
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Du XM, Gai H, He SP, Yang ZE, Sun GF, Ma XF, Li N, Zhang XY, Sun JL, Liu M, Jia YH, Pan ZE, Gong WF, Liu ZH, Zhu HQ, Ma L, Liu FY, Yang DG, Wang F, Fan W, Gong Q, Peng Z, Wang LR, Wang XY, Xu SJ, Shang HH, Lu CR, Zheng HK, Huang SW, Lin T, Zhu YX, Li FG. (2018) Resequencing of 243 diploid cotton accessions based on an, updated A genome identifies the genetic basis of key agronomic traits. Nature Genetics, 50: 796-802.
Wu ZG; Yang Y; Huang G; Lin J, Xia YY, Zhu YX (2017) Cotton functional genomics reveals global insight into genome evolution and fiber development, J Genet Genomics, 44：511-518.
Zhang YZ, Jiao Y, Jiao HY, Zhao HB, Zhu YX. (2017) Two-step functional innovation of the stem-cell factors WUS/WOX5 during plant evolution. Mol. Biol. Evol. 34: 640-653.
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Jiao Y, Zhang YZ, Zhu YX (2016). Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants. Science China Life Sciences. 59, 8:825-831
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Li, F.G., Fan, G.Y., Lu, C.R., Xiao, G.H., Zou, C.S., Kohel, R.J., Ma, Z.Y., Shang, H.H., Ma, X.F., Wu, J.Y., Liang, X.M., Huang, G., Percy, R.G., Liu, K., Yang, W.H., Chen, W.B., Du, X.M., Shi, C.C., Yuan, Y.L., Ye, W.W., Liu, X., Zhang, X.Y., Liu, W.Q., Wei, H.L., Wei, S.J., Huang, G.D., Zhang, X.L., Zhu, S.J., Zhang, H., Sun, F.M., Wang, X.F., Liang, J., Wang, J.H., He, Q., Huang, L.H., Wang, J., Cui, J.J., Song, G.L., Wang, K.B., Xu, X., Yu, J.Z., Zhu, Y.X., Yu S.X.. Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1) provides insights into genome evolution. Nat. Biotechnol, 33 (2015),524-530.
Zhang, Y.Z., Jiao, Y., Liu, Z.H., Zhu, Y.X. ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells. Nature communications 2015 doi: 10.1038/ncomms7003.
Li, F. G., Zhu, Y. X., Wang, J. Yu, S. X et al , Genome sequence of the cultivated cotton Gossypium arboretum , Nature Genetics , 2014 , 46: 567-572
Li, Q., Xiao, G. H., and Zhu, Y. X , Single-nucleotide resolution mapping of the Gossypium raimondii transcriptome reveals a new mechanism for alternative splicing of introns , Molecular Plant , 2014 , 7: 829-840
Zhu, Y. X , Regulation of cotton lint growth. In: McGraw-Hill , Yearbook of Science & Technology , 2014 , 319-322
Jin, X., Pang, Y., Jia, F. X., Xiao, G. H., Li, Q., Zhu, Y. X , A potential role for CHH DNA methylation in cotton fiber growth patterns , PLOS ONE , 2013 , 8: e60547
Zhu, Y. X. and Li, F. G , The Gossypium raimondii genome, a huge leap forward in cotton genomics , J. Integrative Plant Biology , 2013 , 55: 570-571
Jin, X., Li, Q., Xiao, G. H., Zhu, Y. X , Using genome-referenced expressed sequence tag assembly to analyze the origin and expression patterns of Gossypium hirsutum transcripts , J. Integrative Plant Biology , 2013 , 55: 576-585
Wang, K. B., Zhu, Y. X. , Wang, J., Yu, S. X. et al , The draft genome of a diploid cotton Gossypium raimondii , Nature Genetics , 2012 , 44: 1098-1103
Li, Q., Jin, X., Zhu, Y. X , Identification and analyses of miRNA genes in allotetraploid Gossypium hirsutum fiber cells based on the sequenced diploid G. raimondii genome , Journal of Genetics and Genomics , 2012 , 39: 351-360
Qin, Y. M. and Zhu Y. X , How cotton fibers elongate: a tale of linear cell-growth mode , Curr. Opin. Plant Biol , 2011 , 14 : 106-111
Wang, H., Mei, W. Q., Qin, Y. M. and Zhu, Y. X , 1-Aminocyclopropane-1-carboxylic acid synthase 2 is phosphorylated by calcium-dependent protein kinase 1 during cotton fiber elongation , Acta Biochim. et Bioph. Sin , 2011 , 43: 654-661
Pang, C.Y., Wang, H., Pang, Y., Xu, C., Jiao, Y., Qin, Y.M., Western, T.L., Yu, S.X. and Zhu, Y.X. , Comparative proteomics indicate that biosynthesis of pectic precursors is important for cotton fiber and Arabidopsis root hair elongation , Molecular Cellular Proteomics , 2010 , 9: 2019-2033
Pang, Y., Wang, H., Song, W. Q. and Zhu, Y. X , The cotton ATP synthase δ1 subunit is required to maintain a higher ATP⁄ADP ratio that facilitates rapid fibre cell elongation , Plant Biology , 2010 , 12: 903-909
Zhu, Y. X , The epigenetic involvement in plant hormone signaling , Chinese Science Bulletin , 2010 , 55: 2198-2203
Mei, W. Q., Qin, Y. M., Song, W. Q., Li, J. and Zhu, Y. X , Cotton GhPOX1 encoding plant class III peroxidase may be responsible for the high level of reactive oxygen species production that is related to cotton fiber elongation , J. Genet. Genomics , 2009 , 36: 141-150
Song, W.Q., Qin, Y.M., Saito, M., Shirai, T., Pujol, F.M., Kastaniotis, A.J., Hiltunen, J.K. and Zhu, Y.X , Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH-binding motif , Journal of Experimental Botany , 2009 , 60: 1839–1848
Han, P. and Zhu, Y. X , BARD1 may be renamed ROW1 because it functions mainly as a REPRESSOR OF WUSCHEL1 , Plant Signaling & Behavior , 2009 , 4: 52-54
Han P, Li Q, Zhu YX , Mutation in the Arabidopsis BARD1 BRCT Domain Releases WUSCHEL Expression from the Organizing Center , The Plant Cell , 2008 , 20:1482-1493
Qu, L. J. and Zhu, Y. X , Transcription factor families in Arabidopsis: major progress and outstanding issues for future research , Curr. Opin. Plant Biol , 2007 , 9: 544-549
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