個人介紹:

王剛博士2010年本科畢業于蘭州大學，2015年博士畢業于北京大學；2015年至2023年先後在哥倫比亞大學和康奈爾大學威爾醫學院從事博士後研究，随後擔任康奈爾大學威爾醫學院講師；2024年7月起任beat365官方网站和北大-清華生命科學聯合中心研究員。王剛博士長期緻力于研究癌症誘導機體多組織器官的系統性病變的機理，在腫瘤誘導肝髒代謝病變、癌症惡液質等方向取得多項原創性成果，在Nature, Nature Medicine, Nature Cell Biology, Cancer Cell等權威期刊發表多篇論文。

教育經曆:

2010年9月-2015年7月，博士，細胞生物學，北京大學
2006年9月-2010年7月，學士，生物科學，蘭州大學

工作經曆:

2024年7月-至今，研究員，beat365官方网站
2024年7月-至今，研究員，北大-清華生命科學聯合中心
2023年10月-2024年6月，講師，康奈爾大學威爾醫學院
2017年10月-2023年10月，博士後，康奈爾大學威爾醫學院
2015年10月-2017年10月，博士後，哥倫比亞大學

榮譽獎勵:

2024　　　　拜耳研究員
2024　　　　億方學者
2015　　　　北京市優秀畢業生
2014　　　　博士研究生國家獎學金
2012　　　　教育部博士研究生學術新人獎
2012　　　　博士研究生國家獎學金

      我們對癌症的理解已經從腫瘤細胞的内部調控擴展到腫瘤與微環境之間複雜的相互作用，并認識到癌症是一種全身系統性疾病。随着腫瘤對全身的影響，它不僅能誘導肝髒與肌肉代謝功能的失調，還導緻了免疫系統功能紊亂；腫瘤不僅能直接調控遠端組織器官的功能，還能通過調節組織器官之間的相互作用而破壞機體穩态。機體穩态的失衡既影響了抗腫瘤治療的療效和預後，也降低了癌症患者的生存率和生活質量。然而，我們對腫瘤誘導的宿主全身系統性病變機理的了解仍然匮乏，這嚴重阻礙了抗腫瘤治療策略的發展，限制了治療癌症及其并發症的效果。

本實驗室從免疫、代謝及惡液質這三個方向深入探究腫瘤誘發宿主體内多組織、器官功能性病變的機理，為治療癌症及其并發症，尤其是惡液質等提供重要的治療靶點，以期提高患者的生存率和生活質量。主要研究方向包括：
1. 探究腫瘤誘導惡液質發生的分子機制
2. 探究腫瘤重塑機體免疫景觀并抑制抗腫瘤免疫的機理
3. 探索抑制腫瘤誘導宿主系統性病變的治療方法

1. Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey A. Klute, Tanya M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang, David Lyden. Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature 2023 June 8; 618, 374–382.
• Highlighted in Nature Reviews Cancer 23, 510 (2023)
• Highlighted in Cancer Discovery (2023) https://doi.org/10.1158/2159-8290.CD-RW2023-086

2. Gang Wang, Candia M. Kenific, Grace Lieberman, Haiying Zhang, David Lyden. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles. In: Acharyya, S. (eds) The Systemic Effects of Advanced Cancer. Springer, Cham. (2022) https://doi.org/10.1007/978-3-031-09518-4_2.

3. Gang Wang, Haiying Zhang, David Lyden. Tumour-regulated anorexia preceding cachexia. Nature Cell Biology 2021 Feb; 23, 111-113.

4. Candia M.Kenific*, Gang Wang*, David Lyden. Tumor extracellular vesicles impede interferon alert responses. Cancer Cell 2019 Jan 14; 35 (1), 3-5. (* Co-First authors)

5. Gang Wang, Anup K. Biswas, Wanchao Ma, Manoj Kandpal, Courtney Coker, Paul M. Grandgenett, Rinku Jain, Kurenai Tanji, Sara Lόpez-Pintado, Alain Borczuk, Doreen Hebert, Supak Jenkitkasemwong, Shintaro Hojyo, Ramana V. Davuluri, Mitchell D. Knutson, Toshiyuki Fukada, Swarnali Acharyya. Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle. Nature Medicine 2018 Jun; 24 (6), 770-781.
• Highlighted in Nature Reviews Cancer 18, 467 (2018)

6. Shruthy Suresh Aggarwal, Cristina Andreani, Zihou Deng, Julia Frede, Polina Kameneva, Marta Kovatcheva, Goran Micevic, Fay Nicolson, Jens Puschhof, Morgan Roberts, Gang Wang#, Dionysios C. Watson. The 2024 generation. Nature Cancer 2024 Dec; 5, 1774–1778. (Invited Viewpoint, # Co-Corresponding author)

7. Gang Wang, Qing Jiang, Chuanmao Zhang. The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. Journal of Cell Science 2014 Oct 1; 127 (19), 4111-4122.

8. Gang Wang, Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang, Chuanmao Zhang. PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. Journal of Cell Science 2013 Mar 15; 126 (6), 1355-1365.
• A featured article in Journal of Cell Science 126 (6): e0605 (2013)
• Highlighted in Nature Reviews Molecular Cell Biology 14, 131 (2013).

9. Wangfei Chi, Gang Wang, Guangwei Xin, Qing Jiang, Chuanmao Zhang. PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations. Journal of Cell Biology 2021 Jan 4; 220 (1): e202002151.

10. Tingting Zhang, Guangwei Xin, Mingkang Jia, Tenghan Zhuang, Shicong Zhu, Boyan Zhang, Gang Wang, Qing Jiang, Chuanmao Zhang. Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1. Journal of Cell Science 2019 Jan 22; 132, jcs220384. doi:10.1242/jcs.220384.

11. Boyan Zhang, Tenghan Zhuang, Qiaoyu Lin, Biying Yang, Xiaowei Xu, Guangwei Xin, Shicong Zhu, Gang Wang, Bin Yu, Tingting Zhang, Qing Jiang, Chuanmao Zhang. Patched1-ArhGAP36-PKA-Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation. PNAS 2019 Jan 15; 116 (3), 874-879.

12. Huabo Chen, Xiaowei Xu, Guopeng Wang, Boyan Zhang, Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, Hongyin Zhang, Chuanmao Zhang. CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells. Journal of Biological Chemistry 2017 Jun 16; 292(24):10131-10141.

13. Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang, Chuanmao Zhang. DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6. Nature Communications 2017 Apr 27; 8:15164.

14. Boyan Zhang, Gang Wang, Xiaowei Xu, Sisi Yang, Tenghan Zhuang, Guopeng Wang, He Ren, Steven Y. Cheng, Qing Jiang, Chuanmao Zhang. DAZ-interacting protein 1 (Dzip1) phosphorylation by Polo-like kinase 1 (Plk1) regulates the centriolar satellites localization of the BBSome during the cell cycle. Journal of Biological Chemistry 2017 Jan 27; 292(4):1351-1360.

15. Ran Qi, Nan Xu, Gang Wang, He Ren, Si Li, Jun Lei, Qiaoyu Lin, Lihao Wang, Xin Gu, Hongyin Zhang, Qing Jiang, Chuanmao Zhang. Lamin-A/C/LAP2α/BAF1 protein complex regulates the mitotic spindle assembly and positioning. Journal of Cell Science 2015 Aug 1; 128(15):2830-41.

16. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou, Qing Jiang, Chuanmao Zhang. Spatial compartmentalization specializes function of Aurora-A and Aurora-B. Journal of Biological Chemistry 2015 Jul 10; 290(28):17546-58.

17. Boyan Zhang, Tingting Zhang, Guopeng Wang, Gang Wang, Wangfei Chi, Qing Jiang, Chuanmao Zhang. GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PloS Biology 2015 Apr; 13(4): e1002129.

18. Wenxiang Fu, Hao Chen, Gang Wang, Jia Luo, Zhaoxuan Deng, Guangwei Xin, Nan Xu, Xiao Guo, Jun Lei, Qing Jiang, Chuanmao Zhang. Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly. PNAS 2013 Sep 17; 110 (38), 15295-15300.