教育經曆:

2002年2月 - 2003年8月 , 博士後 , 德國Ruhr大學 , （德國洪堡基金資助）
1999年10月- 2001年9月, 博士後 , beat365官方网站
1993年8月 - 1999年9月, 畢業 , 生物化學 , 芬蘭奧魯大學 (University of Oulu, Finland) , 哲學博士
1989年9月 - 1993年7月, 理學碩士 , 生物化學 , 挪威奧斯陸大學(University of Oslo, Norway)
1983年9月 - 1988年7月 , 理學學士 , 北京大學醫學部藥學院

工作經曆:

2008年8月 - 至今 , 教授 , beat365官方网站
2007年8月 - 至今 , 博士生導師 , beat365官方网站
2001年8月 - 2008年7月 , 副教授 , beat365官方网站
1988年8月 - 1989年8月 , 實習研究員 , 中國康複研究中心

社會服務工作:

2014年 - 至今 , 中國生物化學與分子生物學教學分會副主任兼秘書長

榮譽獎勵:

德國洪堡基金（Alexander von Humboldt Foundation） , 2002-2003
北京大學優秀教學獎 2016

雜志任職:

2012年-至今 Biochemistry and Molecular Biology, Editor

2011年-至今 農業生物技術學報， 編委

教材編撰:

《生物化學》（第4版），高等教育出版社

執教課程:

生物化學及生物化學小班讨論課 , 授課 , 北京大學 , 2002年9月-至今

      本實驗室主要興趣在于：
　　植物超長鍊脂肪酸合成途徑的研究。
　　脂質代謝途徑調控棉花纖維發育的分子機制研究。
　　棉花脂質組學研究　　
　　脂肪酸是指一端含有一個羧基的長的脂肪族碳氫鍊,在生物體内大部分脂肪酸都以脂質形式存在。超長鍊脂肪酸是指碳骨架長度超過20個碳原子的脂肪酸，在植物體内這類脂肪酸主要集中于細胞膜鞘脂及植物表面蠟質中，其生物學作用不很清楚。
　　實驗室以陸地棉和無長絨無短絨突變體為實驗材料，通過構建大規模棉花轉錄組基因芯片，分離、鑒定和研究棉花纖維伸長相關基因。其中，超長鍊脂肪酸（VLCFA）合成途徑是被鑒定為一條重要的在纖維發育期顯著上調的代謝途徑，我們克隆并鑒定編碼3-酮脂酰-CoA合酶、3-酮脂酰-CoA還原酶及烯酰-CoA還原酶的棉花cDNA。為驗證其生物學功能，将它們互補相對應的酵母突變體中，并使用氣相色譜質譜聯用儀對互補棉花基因的酵母突變體中的脂肪酸進行定性和定量分析，研究發現VLCFA通過激活乙烯合成途徑不僅能夠促進棉纖維伸長發育，而且還能促進拟南芥莖細胞伸長。這是關于VLCFA可能作為植物信号分子的首次報道，對于VLCFA如何調控植物發育的進一步研究具有重要意義。利用超高效液相色譜質譜聯用（ESI-MS/MS）技術，對六類棉纖維中的甘油磷脂建立了共計1566對離子對的脂質組學MRM檢測方法。提取開花後10天（10 dpa）野生型陸地棉纖維、胚珠及無毛突變體（fuzzless-lintless）中的總脂質。實驗結果表明，10 dpa纖維細胞中磷脂酰肌醇PI34:3的含量明顯高于胚珠及無毛突變體中的含量，其中脂肪酸鍊組成是棕榈酸C16:0和亞麻酸C18:3。在胚珠體外培養實驗中，外源施加包含C18:3的PI或C18:3均能夠顯著促進纖維細胞的伸長。磷脂酰肌醇合酶PIS抑制劑5-Hydroxytryptamine抑制纖維細胞伸長。病毒誘導的基因沉默實驗結果表明，抑制GhPIS導緻顯著的纖維變短表型。

1. Liu NJ, Zhang T, Liu ZH, Chen X, Guo HS, Ju BH, Zhang YY, Li GZ, Zhou QH, Qin YM*, Zhu YX (2020). Phytosphinganine Affects Plasmodesmata Permeability via Facilitating PDLP5-Stimulated
Callose Accumulation in Arabidopsis. Mol. Plant. 13, 128–143.
2.Wang XC, Li Q, Jin X, Xiao GH, Liu GJ, Liu NJ, Qin YM* (2015) Quantitative proteomics and transcriptomics reveal key metabolic processes associated with cotton fiber initiation. J Proteomics. 114, 16-27.
3.Liu GJ, Xiao GH, Liu NJ, Liu D, Chen PS, Qin YM*, Zhu YX. (2015) Targeted lipidomics studies reveal that linolenic acid promotes cotton fiber elongation by activating phosphatidylinositol and phosphatidylinositol monophosphate biosynthesis. Mol Plant. 8, 911-921.
4.Epstein S, Castillon GA, Qin Y*, and Riezman H* (2012) An essential function of sphingolipids in yeast cell division. Mol Microbiol. 84, 1018-1032
5. Wang H, Mei W, Qin Y* and Zhu Y , 1-Aminocyclopropane-1-carboxylic acid synthase 2 is phosphorylated by calcium-dependent protein kinase 1 during cotton fiber elongation. , Acta Biochim Biophys Sin , 2011 , 43: 654-661
6. Qin YM, Zhu YX , How cotton fibers elongate: a tale of linear cell-growth mode , Curr Opin Plant Biol , 2011 , 14: 106-111
7. Pang CY, Wang H, Pang Y, Xu C, Jiao Y, Qin YM, Western TL, Yu SX, Zhu YX , Comparative proteomics indicates that biosynthesis of pectic precursors is important for cotton fiber and Arabidopsis root hair elongation. , Mol Cell Proteomics , 2010 , 9: 2019-2033
8. Pang Y, Song WQ, Chen FY, Qin YM* , A new cotton SDR family gene encodes a polypeptide possessing aldehyde reductase and 3-ketoacyl-CoA reductase activities. , Biochemistry (Mosc). , 2010 , 75: 320-326.
9. Song WQ, Qin YM*, Saito M, Shirai T, Pujol FM, Kastaniotis AJ, Hiltunen JK, Zhu YX , Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH binding motif , J Exp Bot , 2009 , 60: 1839-1848
10. Mei WQ, Qin YM*, Song WQ, Li J, Zhu YX , Cotton GhPOX1 encoding plant class III peroxidase may be responsible for the high level of reactive oxygen species production that is related to cotton fiber elongation , J Genet Genomics , 2009 , 36: 141-150.,(* corresponding author)
11. Song WQ, Qin YM*, Saito M, Shirai T, Pujol FM, Kastaniotis AJ, Hiltunen JK, Zhu YX , Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH binding motif , J Exp Bot , 2009 , 60: 1839-1848
12. Mei WQ, Qin YM*, Song WQ, Li J, Zhu YX , Cotton GhPOX1 encoding plant class III peroxidase may be responsible for the high level of reactive oxygen species production that is related to cotton fiber elongation , J Genet Genomics , 2009 , 36: 141-150.,(* corresponding author)
13. He XC, Qin YM*, Xu Y, Hu CY, Zhu YX , Molecular cloning, expression profiling and yeast complementation of nineteen beta-tubulin cDNAs from developing cotton ovules , J Exp Bot , 2008 , 59: 2687-2695
14. He XC, Qin YM*, Xu Y, Hu CY, Zhu YX , Molecular cloning, expression profiling and yeast complementation of nineteen beta-tubulin cDNAs from developing cotton ovules , J Exp Bot , 2008 , 59: 2687-2695
15. Qin YM , Hu CY, Pang Y, Kastaniotis AJ, Hiltunen JK and Zhu YX , Saturated very-long-chain fatty acids promote cotton fiber and Arabidopsis cell elongation by activating ethylene biosynthesis , Plant Cell , 2007 , 19: 3692-3704
16. Qin YM*, Pujol FM, Hu CY, Feng JX, Kastaniotis AJ, Hiltunen JK, and Zhu YX , Genetic and biochemical studies in yeast reveal that the cotton fibre-specific GhCER6 gene functions in fatty acid elongation , J Exp Bot, , 2007 , 58: 473-481
17. Li HB, Qin YM*, Pang Y, Song WQ, Mei WQ, and Zhu YX , A cotton ascorbate peroxidase is involved in hydrogen peroxide homeostasis during fibre cell development , New Phytologist , 2007 , 175: 462-471,
18. Qin YM and Zhu YX , A brief summary of major advances in cotton functional genomics and molecular breeding studies in China , Chin Sci Bull , 2007 , 52, 3174-3178,Review
19. Qin YM , Hu CY, Pang Y, Kastaniotis AJ, Hiltunen JK and Zhu YX , Saturated very-long-chain fatty acids promote cotton fiber and Arabidopsis cell elongation by activating ethylene biosynthesis , Plant Cell , 2007 , 19: 3692-3704
20. Qin YM*, Pujol FM, Hu CY, Feng JX, Kastaniotis AJ, Hiltunen JK, and Zhu YX , Genetic and biochemical studies in yeast reveal that the cotton fibre-specific GhCER6 gene functions in fatty acid elongation , J Exp Bot, , 2007 , 58: 473-481
21. Li HB, Qin YM*, Pang Y, Song WQ, Mei WQ, and Zhu YX , A cotton ascorbate peroxidase is involved in hydrogen peroxide homeostasis during fibre cell development , New Phytologist , 2007 , 175: 462-471,
22. Qin YM and Zhu YX , A brief summary of major advances in cotton functional genomics and molecular breeding studies in China , Chin Sci Bull , 2007 , 52, 3174-3178,Review
23. Shi, Y.H., Zhu, S.W., Mao, X.Z., Feng, J.X., Qin, Y.M., Zhang, L., Cheng, J., Wei. L.P., Wang, Z.Y., and Zhu, Y.X , Transcriptome profiling, molecular biological, and physiological studies reveal a major role for ethylene in cotton fiber cell elongation , Plant Cell , 2006 , 18, 651-664
24. Qin YM, Pujol FA, Shi YH, Feng JX, Liu YM, Kastaniotis AJ, Hiltunen JK and Zhu YX , Cloning and functional characterization of two cDNAs encoding NADPH-dependent 3-ketoacyl-CoA reductases from developing cotton fibers , Cell Research , 2005 , 15: 465-473.
25. Qin YM, Poutanen MH, and Novikov DK , Substrate specificities of peroxisomal members of short-chain alcohol dehydrogenase superfamily: expression and characterization of dehydrogenase part of Candida tropicalis multifunctional enzyme , J Lipid Res. , 2000 , 41: 93-98
26. Hiltunen JK and Qin YM , beta-Oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters , Biochim Biophys Acta , 2000 , 1484, 117-128,Review
27. Qin YM, Haapalainen AM, Kilpelainen SH, Marttila MS, Koski MK, Glumoff T, Novikov DK, and Glumoff T , Human peroxisomal multifunctional enzyme type 2. Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity , J Biol Chem, , 2000 , 275: 4965-4972
28. Qin YM, Marttila MS, Haapalainen AM, Siivari KM, Glumoff T, and Hiltunen JK , Yeast peroxisomal multifunctional enzyme: (3R)-hydroxyacyl-CoA dehydrogenase domains A and B are required for optimal growth on oleic acid , J Biol Chem, , 1999 , 274: 28619-28625.
29. Qin YM, Haapalainen AM, Conry D, Cuebas DA, Hiltunen JK, and Novikov DK , Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis , Biochem J, , 1997 , 328: 377-382.