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張蔚

郵  箱: weizhangvv (AT) pku.edu.cn

職  稱:教授

辦公室電話:62767697

辦公室地址:北京市海澱區頤和園路5号,北京大學,金光生命科學大樓,100871

所屬實驗室:張蔚實驗室

實驗室電話:62767697

實驗室地址:北京市海澱區頤和園路5号,北京大學,金光生命科學大樓,100871

實驗室主頁

https://www.weizhanglab.net/

複制成功
  • 個人簡介
  • 科研領域
  • 代表性論文

教育經曆:

2005-2011 博士,beat365官方网站
2001-2005 學士,山東大學beat365

工作經曆:

2025年-至今 教授(長聘) beat365官方网站
2025年-至今 教授(長聘) 北大清華生命科學聯合中心
2024年-2025年 研究員(長聘) beat365官方网站
2024年-2025年 研究員(長聘) 北大清華生命科學聯合中心
2018年-2024年 研究員 beat365官方网站
2018年-2024年 研究員 北大清華生命科學聯合中心
2012年-2017年 博士後 芝加哥大學生态與演化系
2012年 博士後 芝加哥大學兒科系

榮譽獎勵:

北京大學優秀班主任标兵,2024
周堯昆蟲分類學獎勵基金一等獎,2024
北京大學優秀博士學位論文指導教師,2024
博雅特聘教授,2024
生物醫學峰基金,2023
國家傑出青年科學基金,2023
北京大學教學優秀獎,2023
本源公益基金,2023
beat365官方网站最受歡迎教師,2022
黃廷方/信和青年傑出學者獎,2022
北京大學第二十一屆青年教師教學基本功比賽,一等獎、最佳教案獎、最佳教學演示獎、最受學生歡迎獎,2021
綠葉生物醫藥傑出青年學者,2020
北京市傑出青年科學基金,2019
博雅青年學者,2019
億方學者,2019
北京市普通高校本科畢業設計優秀指導教師,2019
北京大學優秀班主任,2019
國家高層次人才引進計劃(青年項目),2018
芝加哥大學博士後聯合會獎學金,2014

學術任職:

2022年-至今 中國昆蟲學會 理事
2019年-至今 中國昆蟲學會青年工作委員會 委員
2019年-至今 中國昆蟲學會昆蟲基因組學專業委員會 委員
2021年-至今 中國昆蟲學會蛾類專業委員會 委員
2022年-至今 中國昆蟲學會蝴蝶分會 委員
2024年-至今 中國動物學會 理事
2021年-至今 中國動物學會生物進化理論專業委員會 副主任委員
2024年-至今 中國野生動物保護協會科技專家委員會 委員
2025年-至今 中國遺傳學會動物遺傳學專業委員會 委員
2024年-至今 北京昆蟲學會 理事
2024年-至今 北京昆蟲學會青年工作委員會 副主任委員
2019年-至今 西藏自治區科學探險協會 副理事長
2021年-至今 蛋白質與植物基因研究國家重點實驗室 學術秘書

雜志任職:

National Science Review 2024年-至今(學科編輯組)
Journal of Systematics and Evolution 2024年–至今(編委)
遺傳 2020年–至今(編委)
Data in Brief 2023年–至今(編委)

執教課程:

現代生物學理論基礎-演化與組學(研、SLS),春季
文獻深度分析讨論課程-演化與組學(研、SLS),春季
進化和群體遺傳學的概念、方法與前沿(本研、SLS),秋季
生态學與演化生物學科研實踐(本),春季、秋季
生物演化(通選課),秋季
生态學科研規範與畢業論文(本),講課,春季
生物信息學(研、PTN),講課,春季
學位論文寫作規範(研、SLS),講課,春季
研究生科學研究規範訓練 (研),講課,秋季
高級發育生物學(研、CLS),講課,秋季
遺傳學基礎(研、CLS),講課,秋季
      我們的研究興趣在于整合實驗和計算生物學的研究方法,探究重要演化問題的理論基礎和分子機理,例如物種形成,适應性性狀以及滲入演化。我們的研究對象通常具有物種豐富,适應性輻射以及不完全生殖隔離等特點。例如,鱗翅目昆蟲物種豐富,存在廣泛種間雜交,并且具有多樣的翅膀花紋,是用于研究适應性演化的經典體系。測序技術和基因編輯技術的迅速發展,使得對于非模式生物在全基因組層面進行演化基因組學和群體遺傳學研究以及進行目标基因的功能鑒定成為可能。我們的主要研究方向包括:葉形拟态的起源和遺傳機制;鱗翅目昆蟲發育過程的雌雄二型;适應性基因漸滲的鑒定,功能研究和演化模型等。
(* equal contribution, # corresponding author)
Pei XJ*, Zhao D*, Luo J, Jia PY, Luo Y, Yuan DW, Hou WX, Zhang ZF, Huang DY, Ni JX, Gao HZ, Chen Z, Luan YX, Chen XX#, Zhang W#, Li S#. Redboy confers programed body color transition in orchid mantis. Nat. Ecol. Evol. accepted

Gao H, Zhao D, Zeng H, Jiang Y, Li J, Zhang W#. Distribution patterns and environmental factors influencing Nymphalidae and Salticidae diversity in the Wuzhishan area of Hainan. iScience 2025 Mar: doi: 10.1016/j.isci.2025.112238.

Xu J#, Zhang W#. From fossils to genomes: decoding the insect world. Natl. Sci. Rev. 2025 Feb 22;12(3):nwaf055.

Yao Z*, Sun X*, Wu X, Zhu F, Huang J, Zhang W#, Ma W#, Hua H, Lin Y. Functional and evolutionary analysis of key enzymes triacylglycerol lipase, glycogen hydrolases in the glycerol and glucose biosynthesis pathway and cellular chaperones for freeze-tolerance of the Rice stem borer, Chilo suppressalis. Int. J. Biol. Macromol. 2024 Oct doi: doi.org/10.1016/j.ijbiomac.2024.136861.

倪嘉欣,張蔚#。蝶翅花紋的演化發育生物學研究進展。遺傳 2024 doi: 10.16288/j.yczz.24-126.(Invited review)

Huang G*, Zhang Y*, Zhang W, Wei F#. Genetic mechanisms of animal camouflage: an interdisciplinary perspective. Trends Genet. 2024 Apr 20:S0168-9525(24)00073-8.

Zhang LJ#*, Shi ZA*, Chen ZY, von Rintelen T, Zhang W, Lou ZJ. Rediscovery and systematics of the enigmatic genus Helicostoa reveals a new species of sessile freshwater snail with remarkable sexual dimorphism. Proc. R. Soc. Lond. B Biol. Sci. Jan 10;291(2024):20231557.

Zhang W#, Lohman DJ. Uncovering the functional basis of mantids that resemble plants. Sci. China Life Sci. 2024 Jan;67(1):215-216.

Yang W, Cui J, Chen Y, Wang C, Yin Y, Zhang W, Liu S, Sun C, Li H, Duan Y, Song F, Cai W, Hines HM, Tian L#. Genetic modification of a Hox locus drives mimetic color pattern variation in a highly polymorphic bumble bee. Mol. Biol. Evol. 2023 Dec 1:msad261.

Teng D, Zhang W#. The diversification of butterfly wing patterns: Progress and prospects. Curr. Opin. Insect Sci. 2023 Nov 3:61:101137. (Invited review)

Wang Z*, Sun J*, Gao Y, Xue Y, Zhang Y, Li K, Zhang W, Zhang C, Zu J#, Zhang L#. Fusang: A framework for phylogenetic tree inference via deep learning. Nucleic Acids Res. 2023 Oct 11: gkad805.(Cover Story)

Wang S, Girardello M, Zhang W#. Potential and progress of studying mountain biodiversity by means of butterfly genetics and genomics. J. Genet. Genomics 2023 Jun 10:j.jgg.2023.06.001 (Invited review)

Zhang Y*, Zhu Q*, Shao Y, Jiang Y, Ouyang Y, Zhang L#, Zhang W#. Inferring historical introgression with deep learning. Syst. Biol. 2023 Nov 1;72(5):1013-1038. (Cover Story)

Zeng H#*, Zhao D*, Zhang Z, Gao H, Zhang W#. Imperfect ant mimicry contributes to local adaptation in a jumping spider. iScience 2023 May 17:106747. (Reported by Cell Magazine, Science Magazine, NY Times, Phys and ScienceDaily)

Zhang W#, Zhang L, Zhang W. Editorial: The origination of genetic novelties: New genes, new regulations, and new cell types. Front. Genet. 2023 Jan 13:1118926.

Ge D*, Wen Z*, Feijo A*, Lissovsky A*, Zhang W*, Chen J, Yan C, She H, Zhang D, Cheng Y, Lu L, Wu X, Mu D, Zhang Y, Xia L, Qu Y#, Vogler AP#, Yang Q#. Genomic consequences and demographic response to pervasive hybridization over time in climate-sensitive pikas. Mol. Biol. Evol. 2022 Dec 23:msac274.

Wu N, Evans E, van Schooten B, Meléndez-Rosa J, Ortiz Y, Planas Soto-Navarro SM, Van Belleghem SM, Counterman BA, Papa R#, Zhang W#. Widespread gene expression divergence in butterfly sensory tissues plays a fundamental role during reproductive isolation and speciation. Mol. Biol. Evol. 2022 Nov 3;39(11):msac225.(Cover Story)

Wang S*, Teng D*, Li X*, Yang P, Da W, Zhang Y, Zhang Y, Liu G, Zhang X, Wan W, Dong Z, Wang D, Huang S, Jiang Z, Wang Q, Lohman DJ, Wu Y, Zhang L, Jia F, Westerman E, Zhang L, Wang W, Zhang W#. The evolution and diversification of oakleaf butterflies. Cell 2022 Aug 18;185:1-15.(Cover Story, reported by Cell, CNS, Phys and ScienceDaily and recommended by Nature Ecology and Evolution Year in Review)

王姝婷*,滕德群*,張蔚#。以枯葉蛱蝶屬為例揭示山地生物多樣性演化和遺傳機制。遺傳 2022 44 (9):731–732.

Wang Y*, Fan Y*, Fan D*, Zhang Y, Zhou X, Zhang R, Wang Y, Sun Y, Zhang W, He Y, Deng XW#, Zhu D#. The Arabidopsis DREAM complex antagonizes WDR5A to modulate histone H3K4me2/3 deposition for a subset of genome repression. Proc. Natl. Acad. Sci. USA 2022 Jul 5;119(27):e2206075119.

He J*, Zhang R*, Yang J*, Chang Z*, Zhu L*, Lu S*, Xie F, Mao J, Dong Z, Liu G, Hu P, Dong Y, Wan W, Zhao R, Xiong T, León-Cortés JL, Mao C, Zhang W, Zhan S, Li J, Chen L#, Wang W#, Li X#. High-quality reference genomes of swallowtail butterflies provide insights into their coloration evolution. Zool. Res. 2022 May 18;43(3):367–379.

Sun T, Song Y, Teng D, Chen Y, Dai J, Ma M, Zhang W, Pastor-Pareja JC#. Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion. Cell Rep. 2021 Sep 7;36(10):109667.

Zhang Y*, Teng D*, Lu W*, Liu M*, Zeng H, Cao L, Southcott L, Potdar S, Westerman E, Zhu AJ#, Zhang W#. A widely diverged locus involved in locomotor adaptation in Heliconius butterflies. Sci. Adv. 2021 Aug 4;7(32):eabh2340.(Cover Story)

Teng D, Li F, Zhang W#. Using comprehensive machine-learning models to classify complex morphological characters. Ecol. Evol. 2021 Jun 27;11(15):10421-10431.

Feng Y*, Xu H*, Liu J*, Xie N, Gao L, He Y, Yao Y, Lv F, Zhang Y, Lu J, Zhang W, Li C, Hu X#, Yang Z#, Xiao R. Functional and adaptive significance of promoter mutations that affect divergent myocardial expressions of TRIM72 in primates. Mol. Biol. Evol. 2021 Mar 21;msab083.

Yang J*, Wan W*, Xie M*, Mao J*, Dong Z*, Lu S, He J, Xie F, Liu G, Dai X, Chang Z, Zhao R, Zhang R, Wang S, Zhang Y, Zhang W#, Wang W#, Li X#. Chromosome-level reference genome assembly and gene editing of the dead-leaf butterfly Kallima inachus. Mol. Ecol. Resour. 2020 Jul;20(4):1080-1092.(Cover Story)

Mullen SP#, VanKuren NW, Zhang W, Nallu S, Kristiansen EB, Wuyun Q, Liu K, Hill RI, Briscoe AD, Kronforst MR. Disentangling population history and character evolution among hybridizing lineages. Mol. Biol. Evol. 2020 Jan 13;pii: msaa004.

Zhang W#, Leon-Ricardo BX, van Schooten B, Van Belleghem SM, Counterman BA, McMillan WO, Kronforst MR, Papa R. Comparative transcriptomics provides insights into reticulate and adaptive evolution of a butterfly radiation. Genome Biol. Evol. 2019 Sep 13;11(10):2963-2975.

Chen J*#, Huang Y*, Brachi B*, Yun Q*, Zhang W, Lu W, Li H, Li W, Sun X, Wang G, He J, Zhou Z, Chen K, Ji Y, Shi M, Sun W, Yang Y#, Zhang R#, Abbott RJ#, Sun H#. Genome-wide analysis of Cushion willow provides insights into alpine plant divergence in a biodiversity hotspot. Nat. Commun. 2019 Nov 19;10(1):5230.

Westerman E*, VanKuren N*, Massardo D, Tanger-Trolander A, Zhang W, Hill RI, Perry M, Bayala E, Barr K, Chamberlain N, Douglas TE, Buerkle N, Palmer S, Kronfost MR#. Aristaless controls butterfly wing color variation used in mimicry and mate choice. Curr. Biol. 2018 Nov 5;28(21):3469-3474.e4.

Nallu S, Hill JA, Don K, Sahagun C, Zhang W, Meslin C, Snell-Rood E, Clark NL, Morehouse NI, Bergelson J, Wheat CW, Kronforst MR#. The molecular genetic basis of herbivory between butterflies and their host-plants. Nat. Ecol. Evol. 2018 Sep;2(9):1418-1427. (Reported by Nature Plants)

Zhang W, Westerman E, Nitzany E, Palmer S, Kronforst MR#. Tracing the origin and evolution of supergene mimicry in butterflies. Nat. Commun. 2017 Nov 7;8(1):1269. (Reported by University of Chicago, PBS, and ScienceDaily)

Zhang W#, Dasmahapatra KK, Mallet J, Moreira GR, Kronforst MR#. Genome-wide introgression among distantly related Heliconius butterfly species. Genome Biol. 2016 Feb 27;17(1):25. (Research highlighted by Genome Biology)

Li X*, Fan D*, Zhang W*, Liu G*, Zhang L*, Zhao L, Fang X, Chen L, Dong Y, Chen Y, Ding Y, Zhao R, Feng M, Zhu Y, Feng Y, Jiang X, Zhu D, Xiang H, Feng X, Li S, Wang J, Zhang G, Kronforst MR#, Wang W#. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nat. Commun. 2015 Sep 10;6:8212.

Zhan S#, Zhang W, Niitepold K, Hsu J, Fernández Haeger J, Zalucki M, Altizer S, De Roode J, Reppert S, Kronforst MR#. The genetics of monarch butterfly migration and warning colouration. Nature. 2014 Oct 16;514(7522):317-21. (Reported by Nature News & Views, Science Magazine, NY Times, National Geographic, Washington Post and NBC News)

Kunte K*#, Zhang W*, Tenger-Trolander A, Palmer D, Martin A, Reed RD, Mullen SP, Kronforst MR#. doublesex is a mimicry supergene. Nature. 2014 Mar 13;507(7491):229-32. (Recommended by Faculty of 1000, reported by Nature News & Views, Nature Magazine, Science Magazine, NY Times, LA Times, Chicago Tribune and University of Chicago and included in An Introduction to Molecular Evolution and Phylogenetics, 2016 Edition and Genetics: From Genes to Genomes (Hartwell), 2017 Edition)

Kronforst MR#, Hansen MEB, Crawford NG, Gallant JR, Zhang W, Kulathinal RJ, Kapan DD, Mullen SP#. Hybridization reveals the evolving genomic architecture of speciation. Cell Rep. 2013 Nov 14;5(3):666-77. (Selected as Cell Report Best of 2013 and reported by Science Magazine, The Economist, LA Times and University of Chicago)

Zhang W, Kunte K, Kronforst MR#. Genome-wide characterization of adaptation and speciation in tiger swallowtail butterflies using de novo transcriptome assemblies. Genome Biol. Evol. 2013;5(6):1233-45. (Cover Story)

Yang C, Zhang W, Ren M, Song L, Li T#, Zhao J#. Whole-genome sequence of Microcystis aeruginosa TAIHU98, a nontoxic bloom-forming strain isolated from Taihu Lake, China. Genome Announ. 2013 Jun 1(3). pii: e00333-13.

Hu Y, Zhang X, Shi Y, Zhou Y, Zhang W, Su XD, Xia B, Zhao J#, Jin C#. Structures of Anabaena calcium-binding Protein CcbP: insights into Ca2+ signaling during heterocyst differentiation. J Biol. Chem. 2011 Apr 286(14): 12381-12388.

Shi Y*, Zhao W*, Zhang W, Ye Z, Zhao J#. Regulation of intracellular free calcium concentration during heterocyst differentiation by HetR and NtcA in Anabaena sp. PCC 7120. Proc. Natl. Acad. Sci. USA 2006 Jul 103(30): 11334-11339.

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