教育經曆:

2005-2011 博士，美國威斯康辛大學麥迪遜分校
2003-2005 碩士，美國波士頓大學
1999-2003 學士，台灣成功大學

工作經曆:

2017-至今　　研究員， beat365官方网站
2017-至今　　研究員， 北大清華生命科學聯合中心
2011-2017　　博士後，美國麻省理工學院懷特黑德生物醫學研究所

榮譽獎勵:

Charles H. Hood基金會博士後獎學金，2015
美國心髒學會博士研究生獎學金，2009

執教課程:

Advanced Cell Biology

      李湘盈課題組專注于探索幹細胞「自我更新及分化」的分子機理，特别是細胞内信号通路如何與外在環境因素交互作用并影響幹細胞的命運。幹細胞「自我更新」和「分化」之間的平衡對于器官正常發育及組織再生起到關鍵性的作用。為了更深入的了解調控幹細胞自我更新與複制的機制，課題組以血液幹細胞特别是紅系發育為模型。紅細胞是人體内數量最多的細胞，正常人體每秒鐘需制造約三百萬的紅細胞, 以維持體内正常供氧的需求。 李湘盈研究員過去的研究中，通過運用人類基因組學，化學藥物篩選以及單細胞RNA測序技術，發現多種影響紅系祖細胞BFU-E與其他血液幹細胞自我複制的新機制, 研究成果發表於Nature, Molecular Cell, PNAS, Blood等期刊。

　　課題組以血液系統為基礎，結合人類遺傳學，細胞生物學及生物化學，系統性地分析調控幹細胞特别是血液幹細胞複制與分化的機制，從而發現新的調控因子，并進一步理解血液疾病的緻病機理以及開發新的治療方法。

(*Equal contribution)
1. Hu, Q.*, Liu, Y.*, Yue, Q., Zhou, S., Jin, X., Lin, F., Huang, X.J., Zhuang, J.#, Lu, J.#, Gao, X.# and Lee, H.Y.# (2024) Lenalidomide-induced pure red cell aplasia is associated with elevated expression of MHC-I molecules on erythrocytes. Nature Communications. 15, 10131. https://doi.org/10.1038/s41467-024-54571-w
2. Liu, Y.*, Nie, X.*, Yao, X.*, Shou, H., Yang, Y., Ge, Y., Tong, X.#, Lee, H.Y.# and Gao, X.# (2024) Developing an erythrocyte-MHC-I conjugate for cancer treatment. Cell Discovery. 10, 99. https://doi.org/10.1038/s41421-024-00713-9
3. Wu, S.*, Deng, Y.*, Sun, H., Liu, X., Zhou, S., Zhao H., Li, H., Guo, F., Yue, Q., Wu, F., Zhao, X., Li, N., Zhu, S., Hu, Q., Xie, S., Zheng, J., Lv, M., Kong, Y., Huang, X.J., Lei, X., Tong, X.# and Gao, X.# and Lee, H.Y.# (2024) BRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK signaling. Signal Transduction and Targeted Therapy. 9, 338. https://doi.org/10.1038/s41392-024-02033-6
4. Zhu, S.*, Zhang, X.*, Li, N.*, Zhao, X., Li, M., Xie, S., Yue, Q., Li, Y., Li, D., Wu, F., Zhang, Z., Feng, Z., Choi, W., Jia, X., Deng, Y., Hu, Q., Yao, X., Gao, X. and Lee, H.Y. (2024) MED26-enriched condensates drive erythropoiesis through modulating transcription pausing. eLife. https://doi.org/10.7554/eLife.102023.1.sa4
5. Li, D., Zhao, X.Y., Zhou, S., Hu, Q., Wu, F. and Lee H.Y. (2023) Multidimensional profiling reveals GATA1-modulated stage-specific chromatin states and functional associations during human erythropoiesis. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad468
6. Li, D.*, Wu, F.*, Zhou, S., Huang, X.J. and Lee H.Y. (2023) Heterochromatin rewiring and domain disruption-mediated chromatin compaction during erythropoiesis. Nature Structural & Molecular Biology. https://doi.org/10.1038/s41594-023-00939-3
7. Gao, X.*, Lee, H.Y.*, Li, W., Platt, R.J., Barrasa, M.I., Ma, Q., Elmes, R.R., Rosenfeld, M.G. and Lodish, H.F. (2017) Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proceedings of the National Academy of Sciences USA. 114(38), 10107-10112.
8. Gao, X.*, Lee, H.Y.*, da Rocha, E.L., Zhang, C., Lu, Y.F., Li, D., Feng, Y., Ezike, J., Elmes, R.R., Barrasa, M.I., Cahan, P., Li, H., Daley, G.Q. and Lodish, H.F. (2016) TGF-β inhibitors stimulate red cell production by enhancing self-renewal of BFU-E erythroid progenitors. Blood. 128(23), 2637-2641.
9. Lee, H.Y.*, Gao, X.*, Barrasa, M.I., Li, H., Elmes, R.R., Peters, L.L. and Lodish, H.F. (2015) PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal. Nature. 522, 474-7.
10. Lee, H.Y., Johnson, K.D., Boyer, M. E. and Bresnick, E. H. (2011) Relocalizing genetic loci into specific subnuclear neighborhoods. Journal of Biological Chemistry. 286, 18834-18844.
11. Fujiwara, T.*, Lee, H.Y.*, Sanalkumar, R.* and Bresnick, E. H. (2010) Building multifunctionality into a complex containing master regulators of hematopoiesis. Proceedings of the National Academy of Sciences USA. 107, 20429-34.
12. Lee, H.Y., Johnson, K. D., Fujiwara, T., Boyer, M. E., Kim, S.-I. and Bresnick, E. H. (2009) Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor. Molecular Cell. 36, 984-995.