教育經曆:

1996-1999，博士，東北師範大學beat365
1993-1996，碩士，東北師範大學beat365
1985-1989，學士，東北林業大學beat365

工作經曆:

2001 - 至今，beat365官方网站講師，副教授，教授
2006 - 2007，Visiting Scholar, DKFZ, 德國國家癌症中心
2002 - 2005，Postdoctoral fellow, University of Wisconsin at Madison，美國威斯康星大學麥迪遜分校生物化學系
1999 - 2001，博士後，beat365官方网站細胞生物學專業

榮譽獎勵:

北京大學東寶獎教金 , 2015
北大第五屆青年教師教學基本功演示競賽三等獎 , 2009
教育部自然科學獎二等獎, 2007

學術任職:

科技部國家重點研發計劃項目首席科學家
北京大學倫理委員會委員
中國老年醫學學會基礎與轉化醫學分會委員
中國生物物理學會衰老分會理事
中國生理學會衰老與健康專業委員會委員

執教課程:

細胞衰老與死亡（研究生）
生命科學原理與前沿（本科生）
衰老生物學（本科生）
細胞生物學（本科生）

      作為第二遺傳密碼，表觀遺傳通過一維的組蛋白和DNA的修飾以及三維的空間結構來調控基因的表達以及基因組的穩定等。表觀遺傳各種修飾酶活複合體導緻多種多樣的組蛋白和DNA的化學修飾，這些修飾以動态的和組合的方式來應答細胞各種信号從而影響基因組的穩定性以及基因轉錄的活躍、休克和沉默。而基因的轉錄活動和穩定性調控着細胞的各種重大生命活動，如癌化和和衰老。

　　 細胞癌化和衰老是一個多種信号激發的、由多層次信号應答網絡協調的和受表觀遺傳調控的細胞重大生命活動。實驗室目前主要研究基因表達與表觀遺傳互作對細胞癌化、衰老和相關疾病的調控作用和表觀遺傳的編程規律。
　　　　
　　 關鍵科學問題：
　　　　　　1.研究衰老過程中表觀遺傳編程性變化的作用機制，利用合成生物學鑒别個體衰老的關鍵信号通路；
　　　　　　2.篩選幹預細胞和個體衰老的化學小分子；利用表觀遺傳遺傳編輯轉換衰老細胞的命運抉擇。
　　　　　　3 研究衰老相關的神經退行性病變的發病機制和表觀遺傳的調控作用。
　　　　　　3.解析癌化中的表觀遺傳組、空間轉錄組以及三維基因組的變化規律和潛在機制。
　　　　　　
　　　　　　　　 本實驗室招收生信專業或有相關背景的将畢業的本科和碩士生讀博。

Min Yang,Jennie Ong,Fanju Meng,Feixiang Zhang,Hui Shen,Kerstin Kitt,Tengfei Liu,Wei Tao and Peng Du*. Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells. Cell, 2023, in print

Zhou JT†, Zhang C†, Wei R†, Han M, Wang S, Yang K, Zhang L, Chen W, Wen MZ, Li C, Tao W* and Yuan YJ*. (2021). Exogenous artificial DNA forms chromatin structure with active transcription in yeast.Sci China Life Sci, 2022，65: 851–860

Xiaoke Huang†,Xuebin Zhang†,Le Zong，Qianqian Gao，Chao Zhang，Ran Wei,Yiting Guan,Li Huang,Lijun Zhang, Guoliang Lyv* and Wei Tao*.Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3. Journal of Biological Chemistry, 2021，297(4) 101195

Bo He†, Chao Zhang†, Xiaoxue Zhang†, Yu Fan†, Hu Zeng, Jun`e Liu, Haowei Meng, Dongsheng Bai, Jinying Peng, Qian Zhang*, and Wei Tao* and Chengqi Yi*.Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nature Communications,2021, 12: 0-4249

Chao Zhang†,Xuebin Zhang†,Li Huang,Yiting Guan,Xiaoke Huang,XiaoLi Tian,Lijun Zhang and Wei Tao*. ATF3 drives senescence by reconstructing accessible chromatin profiles. Aging Cell, 2021, 20(3): e13315

Yiting Guan†, Chao Zhang†, Guoliang Lyu, Xiaoke Huang, Xuebin Zhang, Tenghan Zhuang, Lumeng Jia, Lijun Zhang, Chen Zhang*, Cheng Li* and Wei Tao*. Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts. Nucleic Acids Research, 2020, 48：10909–10923

Chao Zhang†, Zihan Xu†, shangda Yang†, Guohua Sun, Lumeng Jia, Lumeng Jia, Zhaofeng Zheng, Quan Gu, Wei Tao*, Hui Cheng*, Cheng Li* and Tao Cheng*. Chromatin architecture landscape in hematopoietic stem and progenitor cell populations. Cell Reports, 2020, 32：108206

Guoliang Lyu#, Yuting Guan# , Chao Zahng, Le Zong, Sun Lei, Xiaoke Huang. Li Huang, Lijun Zhang，Xiaoli Tian，Zhongjun Zhou and Wei Tao*.TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging. Nature Communications, 2018,Jul 2;9(1):2560

Meng Chen#, Guoliang Lyu#, Miao Han#, Hongbo Nie#, Ting Shen, Wei Chen, Yichi Niu, Yifan Song, Xueping Li, Huan Li, Xinyu Chen, Ziyue Wang, Zheng Xia, Wei Li, Xiao-Li Tian, Chen Ding, Jun Gu, Yufang Zheng, Xinhua Liu, Jinfeng Hu, Gang Wei*, Wei Tao*, Ting Ni.* 3′ UTR lengthening as a novel mechanism in regulating cellular senescence. Genome Research, 2018, 28: 285-294

Guoliang Lyu, Chao Zhang, Te Ling, Rui Liu, Le Zong, Yiting Guan, Xiaoke Huang, Lei Sun, Lijun Zhang, Cheng Li*, Yu Nie* and Wei Tao*. Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease. BMC Genomics, 2018 19:428

Kai Liu, Lianggong Ding, Yuhong Li, Hui Yang, Chunyue Zhao, Ye Lei , Shuting Han, Wei Tao, Dengshun Miao, Hermann Steller, Michael Welsh* and Lei Liu*.Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. PNAS. 2014,111:13960-65

Min Luo#, Te Ling#, WenbingXie#, He Sun, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Yun Zhao, Tao Ye, Jun Gu, Wei Tao*, Zhigang Lu*, Ingrid Grummt*. NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells, 2013, 31:1278-86

Guoliang Lyu, Le Zong, Chao Zhang, Xiaoke Huang, Wenbing Xie, Junnan Fang, Yiting Guan, Lijun Zhang, Ting Ni#, Jun Gu#, Wei Tao# . Metastasis-related methyltransferase Merm1 represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation. Journal of Molecular Cell Biology, 2019, 11(1), 78–90

Ling T, Xie W, Luo M, Shen M, Zhu Q, Zong L, Zhou T, Gu J, Lu Z, Zhang F, Tao W* , CHD4 maintains demethylation state of rDNA promoters through inhibiting the expression of the rDNA methyltransferase recruiter TIP5 , Biochem Biophys Res Commun, 2013, 19:101-107

Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg HG, Grummt I*, Tao W* , The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions, PNAS, 2012, 109:8161-8166

Guanghliang LV, Tan Tan, Zong L, Yuting Guan， Lei Sun, Liang QJ* and Tao W*, Changes in the position and volume of inctive X Chromosomes during G0/G1 trnasition, Chromosome Research, 2018, 26：179-189