教育經曆:

2001 - 2006 , 理學博士 , 生物化學與分子生物學 , 北京大學
1997 - 2001 , 理學學士 , 生物化學與分子生物學 , 北京大學

工作經曆:

2019.02 - 今　　 博雅特聘教授 beat365官方网站
2018.02 - 2019.01 長聘副教授 beat365官方网站
2012.01 - 2018.01 助理教授 beat365官方网站
2012.01－今　　研究員 北大清華生命科學聯合中心
2006.09－2011.12 博士後 美國梅奧醫學院癌症中心（Mayo Clinic Cancer Center）

社會服務工作:

2022-今 beat365官方网站學術委員會委員
2022-今 beat365官方网站學位委員會委員
2019-今 beat365官方网站生物化學與分子生物學track(本科生)，副主任
2018-今 蛋白質與植物基因研究國家重點實驗室學術委員會 委員
2018-今 全國中學生英才計劃生物委員會專家委員，中國科協
2018-今 北大-清華-NIBS研究生聯合項目培養委員會組長（北大）

榮譽獎勵:

2023 青年創新獎，中國遺傳學會
2022 北京大學優秀研究生導師
2021 北京大學教學優秀獎-本科
2018 入選“北京高校卓越青年科學家”計劃
2017 教育部青年科學獎
2017 國家傑出青年科學基金
2016 北京大學青年教師教學基本功比賽 理工科 二等獎
2015 鄭昌學教學優秀獎
2014 拜耳學者獎
2013 國家優秀青年科學基金
2009 Mayo Clinic“Kendall-Mayo 獎學金”

學術任職:

2019-今 中國遺傳學會表觀遺傳專業委員會副主任委員
2020-今 中國細胞生物學會染色質生物學分會委員
2019-今 中國生物化學與分子生物學會基因專業分會委員　　　　
2018-今 中國病理生理學會系統生物醫學專業委員會委員

執教課程:

分子生物學（本，主講）
表觀遺傳學基礎（本，主講）
綜合實驗課（III）(本）
CLS生物化學與分子生物學模塊（研）
現代生物學實驗技術原理及其應用(研）

      　　 表觀遺傳信息的繼承是生命個體正常發育的基礎，在生殖、發育和衰老等過程中發揮關鍵作用。該過程的失調與多種疾病相關，包括腫瘤、神經退行性病變和早衰等，因而對人類健康産生深遠的影響。表觀遺傳信息的繼承的核心階段發生在細胞周期的S期中的DNA複制過程。伴随DNA複制，母鍊染色質需要解組裝，而在子鍊上需要重建染色質，意味着母鍊表觀遺傳信息在子鍊間的分配和繼承，子代細胞可彈性繼承親本細胞的可遺傳的表觀遺傳信息。
　　本實驗室長期緻力于表觀遺傳信息繼承（Epigenetic Inheritance）的分子機制。我們以芽殖酵母和胚胎幹細胞為研究模式，運用經典的生物化學、遺傳學等方法結合前沿的組學方法、熒光成像等技術，以染色質複制過程為切入點，揭示表觀遺傳信息繼承的基本規律，解析其與基因組穩定性維持，細胞命運決定等的關聯機理。主要研究内容包括：
　　 1.染色質攜帶的表觀遺傳信息的繼承和分配機制：重點關注“新、舊”組蛋白在DNA複制叉兩條子鍊的傳遞機制，闡明該過程對異染色質的建立和維持的影響，探讨其在胚胎發育中的重要作用。
　　 2.染色質組裝機器(包括組蛋白分子伴侶、染色質重塑因子和染色質修飾酶等調節因子)和DNA複制機器（複制體）的“對話”機制：DNA複制和染色質複制偶聯是生命科學的基礎問題之一，這是維持基因組穩定和表觀遺傳組穩定的核心基礎，因此我們長期關注這兩個基本過程的偶聯機制，重點關注染色質組裝對DNA複制反饋的調節機制，以及此過程異常和人類疾病的關系。

1. Ningning Li#, Yuan Gao#, Yujie Zhang#, Daqi Yu#, Jianwei Lin, Jianxun Feng, Jian Li, Zhichun Xu, Yingyi Zhang, Shangyu Dang, Keda Zhou, Yang Liu, Xiang David Li, Bik Kwoon Tye*, Qing Li*, Ning Gao*, and Yuanliang Zhai*. Parental histone transfer caught at the replication fork, Nature, 2024, https://doi.org/10.1038/s41586-024-07152-2
2. Hang Zhao#, Di Li#, Xue Xiao#, Cuifang Liu, Guifang Chen, Xiaoyu Su, Zhenxin Yan, Shijia Gu, Yizhou Wang, Guohong Li, Jianxun Feng, Wei Li, Ping Chen*, Jiayi Yang*, Qing Li*. Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin, iScience, 2024, 27(1): 108537.
3. Yang Liu#, Zhengrong Zhangding#, Xuhao Liu#, Tingting Gan#, Chen Ai, Jinchun Wu, Haoxin Liang, Mohan Chen, Yuefeng Guo, Rusen Lu, Yongpeng Jiang, Xiong Ji, Ning Gao, Daochun Kong, Qing Li, Jiazhi Hu*. Fork coupling directs DNA replication elongation and termination, Science, 2024, 383(6688): 1215-1222
4. Xuezheng Wang#, Yuantao Tang#, Jiawei Xu, He Leng, Guojun Shi, Zaifeng Hu, Jiale Wu, Yuwen Xiu, Jianxun Feng*, Qing Li*. The N-terminus of Spt16 anchors FACT to MCM2–7 for parental histone recycling, Nucleic Acids Research, 2023, 51(21): 11549-11567.
5. Wenlong Du＃, Guojun Shi＃, Chun-Min Shan＃, Zhiming Li＃, Bing Zhu*, Songtao Jia*, Qing Li*, Zhiguo Zhang*.(2022)Mechanisms of chromatin-based epigenetic inheritance. Science China Life Sciences, 65，https://doi.org/10.1007/s11427-022-2120-1 (Review)
6. He Leng＃, Shaofeng Liu＃, Yang Lei, Yuantao Tang, Shijia Gu, Jiazhi Hu, She Chen, Jianxun Feng *, Qing Li*. (2021) FACT interacts with Set3 HDAC and fine-tunes GAL1 transcription in response to environmental stimulation. Nucleic Acids Research, 49:5502-5519
7. Xinlin Xu＃, Yixi Xu＃*, Ruiyuan Guo,Ran Xu ,Congcong Fu, Mengtan Xing, Hiroyuki Sasanuma, Qing Li, Minoru Takata, Shunichi Takeda, Rong Guo *, Dongyi Xu *. (2021) Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress. Nature Structural & Molecular Biology, 28:487–500
8. Yang Liu＃, Chen Ai＃, Tingting Gan＃, Jinchun Wu, Yongpeng Jiang, Xuhao Liu, Rusen Lu, Ning Gao,Qing Li, Xiong Ji, Jiazhi Hu *.(2021) Transcription shapes DNA replication initiation to preserve genome integrity. Genome Biology, 22:176
9. Haoyang Peng＃, Simin Zhang＃, Yihan Peng＃, Shuangyi Zhu, Xin Zhao, Xiaocong Zhao, Shuangshuang Yang, Guangxue Liu, Yang Dong, Xiaoli Gan, Qing Li, Xinghua Zhang, Huadong Pei*, Xuefeng Chen*.(2021) Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination. Advanced Science, 2100753
10. Zhiyun Xu＃, Jianxun Feng* , Qing Li*. (2021) Measuring Genome-Wide Nascent Nucleosome Assembly Using Replication-intermediate nucleosome mapping (ReIN-Map). Methods Molecular Biology (Book) 2196:117-141. doi: 10.1007/978-1-0716-0868-5_10. PMID: 32889717.
11. Tian Tian＃, Min Bu＃, Xu Chen＃,Linli Ding＃, Yulan Yang＃, Jinhua Han, Xin-Hua Feng, Pinglong Xu, Ting Liu, Songmin Ying, Yang Lei, Qing Li, Jun Huang*. (2021) The ZATT-TOP2A-PICH axis drives extensive replication fork reversal to promote genome stability. Molecular Cell 81: 198-211.e6.
12. Yutong Zhang＃, Xiaomin Ou＃, Xuezheng Wang , Dongjie Sun, Xueyin Zhou, Xiaofei Wu, Qing Li, Long Li*. (2020)Structure of the mitochondrial TIM22 complex from yeast. Cell Research, https://doi.org/10.1038/s41422-020-00399-0.
13. Yi Ching Esther Wan＃,Tsz Chui Sophia Leung＃, Dongbo Ding＃, Xulun Sun, Jiaxian Liu,Lina Zhu, Tze Zhen Evangeline Kang, Du Yang, Yuchen Zhang, Jitian Zhang, Chengmin Qian, Michael Shing Yan Huen, Qing Li, Maggie Zi Ying Chow, Zongli Zheng, Junhong Han, Ajay Goel, Xin Wang*, Toyotaka Ishibashi*, Kui Ming Chan*. (2020) Cancer-associated histone mutation H2BG53D disrupts DNA-histone octamer interaction and promotes oncogenic phenotypes. Signal Transduction and Targeted Therapy, 5(1):27 https://doi.org/10.1038/s41392-020-0131-0.
14. Shuqi Li ＃, Ziqi Dong ＃, Shuangshuang Yang, Jianxun Feng, Qing Li *. (2019) Chaperoning RPA during DNA metabolism. Current Genetics, 65: 857-864. (Review)
15. Qing Li*, Xu Zhang, Zhiguo Zhang*. (2018). CHAF1B overexpression: A brake for the differentiation of leukemia cells. Cancer Cell 34:693-694. （Preview）
16. Shuqi Li#, Zhiyun Xu #, Jiawei Xu #, Linyu Zuo, Chuanhe Yu,Pu Zheng, Haiyun Gan, Xuezheng Wang, Longtu Li, Sushma Sharma, Andrei Chabes, Di Li, Sheng Wang, Sihao Zheng, Jinbao Li, Xuefeng Chen, Yujie Sun, Dongyi Xu, Junhong Han, Kuiming Chan, Zhi Qi , Jianxun Feng.*, Qing Li*. (2018) Rtt105 functions as a chaperone for replication protein A to preserve genome stability. The EMBO Journal e99154.
17. Xiaowei Yan#, Jiayi Yang#, Jiawei Xu#,Jianxun Feng*, Qing Li*. (2018). Histone chaperone Spt16p is required for heterochromatin mediated silencing in budding yeast. Protein & Cell 9:652-658.
18. Shengxian Gao, Sumin Feng, Shaokai Ning, Jingyan Liu, Huayu Zhao, Yixi Xu, Jinfeng Shang, Kejiao Li, Qing Li, Rong Guo, Dongyi Xu. (2018) An OB-fold complex controls the repair pathways for DNA double-strand breaks. Nature Communications 9: 3925.
19. Shaofeng Liu#, Zhiyun Xu#,He Leng#, Pu Zheng, Jiayi Yang,Kaifu Chen, Jianxun Feng, Qing Li *. (2017). RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly. Science 355, 415-420.
20. Wei Li＃, Ping Chen＃, Juan Yu, Liping Dong, Dan Liang, Jianxun Feng, Jie Yan, Peng-Ye Wang, Qing Li, Zhiguo Zhang, Ming Li*, Guohong Li*. (2016). FACT remodels the tetranucleosomal unit of chromatin fibers for gene transcription. Molecular Cell 64, 120-133.
21. Jianxun Feng＃, Haiyun Gan＃, Matthew L Eaton, Hui Zhou, Shuqi Li, Jason A Belsky, David M MacAlpine, Zhiguo Zhang*, Qing Li*. (2016). Noncoding transcription is a driving force for nucleosome instability in spt16 mutant cells. Molecular and Cellular Biology 36, 1856-1867. Article of significant interest selected as a Spotlight.
22. Jiayi Yang＃, Xu Zhang＃, Jianxun Feng＃,He Leng, Shuqi Li, Junyu Xiao,Shaofeng Liu, Zhiyun Xu, Jiawei Xu, Di Li, Zhongshi Wang, Jingyang Wang, and Qing Li*. (2016). The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly. Cell Reports 14, 1128-1141.
23. Zhang Xu and Qing Li*. (2014). A role of histone modifications during chromatin replication. Chinese Bulletin of Life Sciences 26, 1176-1186. (In Chinese) (Review)
24. Dan Su#, Qi Hu#, Qing Li#, James R Thompson, Gaofeng Cui, Ahmed Fazly, Brian A Davies, Maria Victoria Botuyan, Zhiguo Zhang* and Georges Mer*. (2012) Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106. Nature 483, 104-107.
25. Qing Li＃, Rebecca Burgess＃and Zhiguo Zhang*. (2012). All roads lead to chromatin: Multiple pathways for histone deposition. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819, 238-46.
26. Qing Li and Zhiguo Zhang* .(2012) Linking DNA replication to heterochromatin silencing and epigenetic inheritance. Acta Biochimica et Biophysica Sinica (ABBS) 44, 3-13. This review was selected as the cover story.
27. Ahmed Fazly, Qing Li, Qi Hu, Georges Mer, Bruce Horazdovsky, and Zhiguo Zhang* .(2012). Histone chaperone Rtt106 promotes nucleosome formation using (H3-H4)2 tetramers. The Journal of Biological Chemistry 2287, 10753-10760.
28. Rebecca J Burgess, Hui Zhou, Junhong Han, Qing Li, and Zhiguo Zhang*. (2012). The SCFDia2 ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing. PLoS Genetics 8, e1002846
29. Junhong Han, Qing Li, Laura McCullough, Charisse Kettelkamp, Tim Formosa, and Zhiguo Zhang* .(2010) Ubiquitylation of FACT by the Cullin-E3 ligase Rtt101 connects FACT to DNA replication. Genes & Development 24, 1485-1490.
30. Qing Li, A M Fazly, Hui Zhou, Shengbing Huang, Zhiguo Zhang* and Bruce Stillman*.(2009) The Elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genetics 5, e1000684.
31. Qing Li#, Hui Zhou#, Hugo Wurtele, Brian Davies, Bruce Horazdovsky, Alain Verreault*, and Zhiguo Zhang*. (2008) Acetylation of Histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell 134, 244-255. Previewed in the same issue. Highlighted in Nature Reviews Molecular Cell Biology, September 2008
32. Pei Han＃, Qing Li＃, and Yu-Xian Zhu*.(2008) Mutation of Arabidopsis BARD1 Causes Meristem Defects by Failing to Confine WUSCHEL Expression to the Organizing Center. The Plant Cell 20, 1482-93.
33. Qing Li＃, Bai-Chen Wang, Yu Xu, and Yu-Xian Zhu*. (2007) Systematic studies of 12S seed storage protein accumulation and degradation patterns during Arabidopsis seed maturation and early seedling germination stages. Journal of Biochemistry and Molecular Biology 40, 373-381.
34. Qing Li, Jian-Xun Feng, Pei Han, and Yu-Xian Zhu*. (2006) Parental RNA is significantly degraded during Arabidopsis seed germination. Journal of Integrative Plant Biology 48, 114-120.

李晴實驗室