教育經曆:

1999 - 2004 , 博士後 , 遺傳學 , Stanford Unversity
1995 - 1999 , 理學博士 , 遺傳學 , Michigan State University
1987 - 1991 , 理學學士 , 生物化學 , 北京大學

工作經曆:

2019 - 至今 教授 (tenure), beat365官方网站
2016 - 至今 研究員, 北京未來基因診斷高精尖創新中心（ICG）
2015 - 至今 研究員, 北大-清華生命科學聯合中心 （CLS）
2014 - 至今 研究員, 北京大學生物醫學集成創新研究所（BIOPIC）
2007 - 至今 研究員, beat365官方网站，生化與分子生物學
2005 - 2007 Research Associate, 美國斯坦福大學醫學院遺傳學系
1999 - 2004 博士後, 美國斯坦福大學醫學院遺傳學系

榮譽獎勵:

北京市先進工作者，2020
“昌聚工程”創業類人才，2020
2019年度中國醫學重大進展獎，2019
北京市留學人員創新創業特别貢獻獎，2019
BI Investigatorship Award, 2019
2018年度beat365官方网站未名傑出科研獎, 2019
第四屆北京大學産學研項目合作先進個人獎, 2019
北京市科學技術獎, 2018
中國科技部創新人才推進計劃科技創新創業人才, 2018
北京大學教學優秀獎, 2018
談家桢生命科學創新獎，2016
中國專利優秀獎，2016
科學中國人年度人物，2016
北京大學鄭昌學教學優秀獎，2015
Bayer Investigator Award，2014
The Roche Chinese Young Investigator Award，2014
北京大學東寶獎教金，2012
beat365官方网站最受歡迎教師獎，2010

學術任職:

beat365官方网站學術委員會委員
北京大學第十屆學位評定委員會生命科學類分會
北京大學交叉學科學術咨詢專家委員會
哈爾濱工業大學基因編輯系統與技術工信部重點實驗室學術委員會委員
出生缺陷遺傳學研究北京市重點實驗室學術委員會委員
啟東産業創新基金專家評委
beat365研究生教學委員會委員
中國藥品注冊審評專家咨詢委員會委員
中國遺傳學會基因組編輯分會副主任
中國生物化學與分子生物學會下屬分子系統生物學專業委員會委員
中國生物化學學會北京分會理事

雜志任職:

Section Editor (Genome Editing and New Technology) for SCIENCE CHINA Life Sciences

      研究領域：
1. 基因編輯技術
2. 新型基因治療及疫苗技術
3. 高通量功能基因組學
4. 重大疾病發生機制　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　

1. Qu L, Yi Z, Shen Y, Lin L, Chen F, Xu Y, Wu Z, Tang H, Zhang X, Tian F, Wang C, Xiao X, Dong X, Guo L, Lu S, Yang C, Tang C, Yang Y, Yu W, Wang J, Zhou Y, Huang Q, Yisimayi A, Liu S, Huang W, Cao Y, Wang Y, Zhou Z, Peng X, Wang J-W, Xie X, and Wei W*. (2022) Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. Cell (in press).
2. Liu Y, Ding B, Zheng L, Xu P, Liu Z, Chen Z, Wu P, Zhao Y, Pan Q, Guo Y, Wang W*, and Wei W*. (2022) Regulatory elements can be essential for maintaining broad chromatin organization and cell viability. Nucleic Acids Research (in press).
3. Li G, Li X, Zhuang S, Wang L, Zhu Y, Chen Y, Sun W, Wu Z, Zhou Z, Chen J*, Huang X*, Wang J*, Li D*, Li W*, Wang H*, and Wei W*. (2022). Gene editing and its applications in biomedicine. Sci China Life Sci 65, https://doi.org/10.1007/s11427-021-2057-0.
4. Yi Z, Qu L, Tang H, Liu Z, Liu Y, Tian F, Wang C, Zhang X, Feng Z, Yu Y, Yuan P, Yi Z, Zhao Y, and Wei W*. (2022) Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nat Biotechnol doi: 10.1038/s41587-021-01180-3.
5. Ding B, Liu Y, Liu Z, Zheng L, Xu P, Chen Z, Wu P, Zhao Y, Pan Q, Guo Y, Wei W*, and Wang W*. (2021) Non-coding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability. Sci. Adv. 7(45), doi: 10.1126/sciadv.abi6020.
6. Zhou Z*, Zhang X, Lei X, Xiao X, Jiao T, Ma R, Dong X, Jiang Q, Wang W, Shi Y, Zheng T, Rao J, Xiang Z, Ren L, Deng T, Jiang Z, Dou Z, Wei W* and Wang J*. (2021) Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection. Sig Transduct Target Ther 6, 382. https://doi.org/10.1038/s41392-021-00800-3.
7. Zhu SY, Liu Y, Zhou Z., Xiao X, Liu ZH, Chen A, Dong XJ, Tian F, Chen SH, Xu YY, Wang CH, Li QH, Niu XR, Pan Q, Du S, Xiao JY*, Wang JW* and Wei W*. (2021). Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. Sci China Life Sci. doi: 10.1007/s11427-021-1990-5.
8. Guo, S., Chen, Y., Liu, J., Zhang, X., Liu, Z., Zhou, Z., and Wei, W*. (2021). Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides difficile toxin B. Sci China Life Sci. doi: 10.1007/s11427-021-1943-9.
9. Xu, P., Liu, Z., Liu, Y., Ma, H., Xu, Y., Bao, Y., Zhu, S., Cao, Z., Wu, Z., Zhou, Z., and Wei, W*. (2021). Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nat Biotechnol. 39(11): 1403-1413.
10. Liang YS, Zhang G*, Li QH, Han L, Hu XY, Guo Y, Tao WY, Zhao XM, Guo MZ, Gan TY, Tong YM, Xu YF, Zhou Z, Ding Q, Wei W*, and Zhong J*. (2021) TRIM26 is a critical host factor for HCV replication and determines host tropism. Sci. Adv. 7(2), doi:10.1126/sciadv.abd9732.
11. Liu Y, Liu Z, Cao Z, and Wei W*. (2020) Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Nat Biotechnol. 38(5): 577-578.
12. Liu L, Zhang Y, Liu M, Wei W, Yi C, and Peng J*. (2019) Structural insights into the specific recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL effectors. Journal of Molecular Biology https://doi.org/10.1016/j.jmb.2019.11.023.
13. Zhang X, Yue D, Wang Y, Zhou Y, Liu Y, Qiu Y, Tian F, Yu Y, Zhou Z, and Wei W*. (2019) PASTMUS: mapping functional elements at single amino acid resolution in human cells. Genome Biology DOI: 10.1186/s13059-019-1897-7.
14. Qu L, Yi Z, Zhu S, Wang C, Cao Z, Zhou Z, Yuan P, Yu Y, Tian F, Liu Z, Bao Y, Zhao Y, Wei W*. (2019) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nat. Biotechnol. 37, 1059-1069.
15. X. Zhao, G. Zhang, X. Chen, L. Dai, X. Qu, S. Li, S. Liu, H. Song, Z. Gao, P. Yuan, Z. Liu, C. Li, Z. Shang, Y. Li, M. Zhang, J. Qi, H. Wang, N. Du, Y. Wu, Y. Bi, S. Gao, Y. Shi, J. Yan, Y. Zhang, Z. Xie*, W. Wei* and G. F. Gao*. (2019) Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Cell 177, 1553-1565.
16. Zhu S, Cao Z, Liu Z, He Y, Wang Y, Yuan P, Li W, Wei W*. (2019) Guide RNAs with embedded barcodes boost CRISPR-pooled screens. Genome Biol 20, 20, doi:10.1186/s13059-019-1628-0.
17. Liu Y, Cao Z, Wang Y, Guo Y, Xu P, Yuan P, Liu Z, He Y, and Wei W*. (2018) Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nat Biotechnol 36, 1203-1210.
18. Zhang H, Zhou Y, Wang Y, Zhao Y, Qiu Y, Zhang X, Yue D, Zhou Z, and Wei W*. (2018). A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis. Sci Rep 8, 1042.
19. Zhang Y, Liu L, Guo S, Song J, Zhu C, Yue Z, Wei W* and Yi C*. (2017) Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition. Nat Commun 8(1): 901.
20. He R, Peng J, Yuan P, Yang J, Wu X, Wang Y and Wei W*. (2017). Glucosyltransferase Activity of Clostridium difficile Toxin B Triggers Autophagy-mediated Cell Growth Arrest. Sci Rep 7(1): 10532.
21. Zhou Y, Wang P, Tian F, Gao G, Huang L*, Wei W* and Xie X.S* (2017) Painting A Specific Chromosome with CRISPR/Cas9 for Live-cell Imaging. Cell Res. 27, 298-301.
22. Hu H, Zhang H, Wang S, Ding M, An H, Hou Y, Yang X, Wei W*, Sun Y*, Tang C*. (2017) Live visualization of genomic loci with BiFC-TALE. Sci. Rep. 7, 40192.
23. Zhou Y, Zhang H and Wei W*. (2016) Simultaneous generation of multi-gene knockouts in human cells. FEBS Letters 590, 4343-4353.
24. Zhu S, Li W, Liu J, Chen C-H, Liao Q, Xu P, Xu H, Xiao T, Cao Z, Peng J, Yuan P, Brown M, Liu X* & Wei W*. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library. Nat Biotechnol 34, 1279-1286.
25. Peng J, Zhou Y, Zhu S and Wei W*. (2015) High-throughput Screens in Mammalian Cells Using the CRISPR-Cas9 System. FEBS Journal 282, 2089–2096.
26. He R, Peng J, Yuan P, Xu F, Wei W*. (2015) Divergent roles of BECN1 in LC3 lipidation and autophagosomal function. Autophagy 11:5, 740-747.
27. Ren Q, Li C, Yuan P, Cai C, Luo G, Zhang L and Wei W*. (2015) A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus. Sci. Rep. 5, 8865.
28. Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, He R, Li C, Guo S, Li S, Huang T, Feng H and Wei W*. (2015) Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res. 25:157-168.
29. Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y and Wei W*. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509: 487-91.
30. Qian LL, Cai CZ, Yuan PF, Jeong SY, Yang XZ, Almeida VD, Ernst J, Costa M, Cohen SN, Wei WS*. (2014) Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake. Sci China Life Sci 57: 469–481.
31. Yang J, Zhang Y, Yuan P, Cai C, Ren Q, Guo S, Zhu C, Qi H and Wei W*. (2014) Complete Decoding of DNA Recognition by TAL Effector RVDs. Cell Res. 24:628-631.

課題組緻力于發展基因編輯技術、新型基因治療及疫苗技術、以及高通量功能基因組學技術，并關注癌症、感染等重大疾病的分子機制研究，為發展高效治療手段提供新的藥物靶點和思路。

實驗室電話10-62756762