個人介紹:

日本東京農工大學獲得博士學位，美國賓西法尼亞州立大學博士後研究員。beat365官方网站教授，博士生導師，生命科學學位分會主席，蛋白質與基因研究國家重點實驗室副主任。擔任國家自然科學基金醫學科學領域學科評審組成員，北京市自然科學基金生物學科組會議評審專家。中國生物化學與分子生物學會蛋白質專業委員會委員，中國生物化學與分子生物學會酶學專業委員會委員、常務委員，中國生物物理學會女科學家分會理事。北京市生物化學與分子生物學學會副理事長。
研究組主要利用生化分子生物學、細胞生物學、免疫學和結構生物學等技術方法，鑒定新的調控腫瘤細胞生長、炎症和固有免疫性疾病的蛋白，包括影響腫瘤轉移和耐藥的外泌體蛋白，研究這些蛋白發揮作用的信号通路和分子機制。探讨泛素化、類泛素化和磷酸化等蛋白質翻譯後修飾在DNA 損傷應答、炎症、腫瘤發生發展中的調控作用及機制，明确蛋白質功能的失調與炎症、腫瘤等重大疾病的發生和發展的關系。
先後主持、承擔了20餘項國家自然科學基金重點項目、面上項目，國際合作ICGEB課題，教育部博士點基金和優先發展基金、國家“重大科學研究計劃”課題，科技部863課題、973課題等多項課題的研究。已經發表多篇SCI文章，其中作為通訊作者發表了68篇文章（Nature Comm,Cell Death Differentiation，PNAS, PLoS Pathogen, Oncogene, Nucleic Acid Res, Cell Res, J Cell Sci, JBC等），合作發表包括Science和PNAS等在内的16篇SCI論文，作為第一作者發表6篇文章。

教育經曆:

1994 - 1998 , 理學博士 , 生化與分子生物學 , 東京農工大學

工作經曆:

2008年6月 - 至今 , 教授 , 北京大學 beat365
2002年5月 - 2008年5月 , 副教授 , 北京大學 beat365
1998年4月 - 2002年4月, 博士後研究員 , 美國 賓夕法尼亞州大學

社會服務工作:

2014年-至今，任beat365學位委員會委員、研究生教育委員會委員。
2012年-至今，任2012級研究生2班班主任工作。

榮譽獎勵:

Bayer學者獎，2020
北京大學優秀博士學位論文指導教師，2020
北京大學優秀教學獎，2017
北京大學優秀班主任，2016
北京大學優秀博士學位論文指導教師，2016
北京大學優秀博士學位論文指導教師，2014
北京大學東寶教師獎 , 2013
北京大學東寶教師獎 , 2009
北京大學青年教師教學基本功優秀獎 , 2007
北京大學東寶教師獎 , 2006
北京市優秀輔導員 , 2006
談家桢基金生命科學九源導師獎 , 2006
北京大學優秀班主任 , 2005

學術任職:

2021年-　　　　　　中國生物化學與分子生物學會蛋白質專業委員會委員
2018年-　　　　　　中國生物化學與分子生物學會理事
2016年-　　　　　　北京生物化學與分子生物學會 副理事長
2015年-至今　　中國生物物理學會女科學家分會理事
2015年-至今　　中國生物化學與分子生物學會酶學專業委員會委員、常務委員
2005年-至今　　中國細胞生物學會會員
2003年-至今　　中國生物物理學會會員
2003年-至今　　中國生物化學與分子生物學會會員
1998年-至今　　美國生物化學學會會員

評審任職:

2005年-至今 中國博士後基金 評審專家
2006年-至今 國家自然科學基金生命學部 評審專家
2006年-至今 山東省自然科學基金生命科學 評審專家
2015年-至今 國家自然科學基金醫學科學領域學科評審組成員，
2015年-至今 北京市自然科學基金生物學科組會議評審專家，
2017年-至今 國家自然科學基金生命科學領域學科評審組成員。

會議發言與組織:

2022-12-10 13th International symposium on DNA Damage Response and Human Diseases. 大會報告
2021-12-11 The 2nd Xi An International Translational Medicine Symposium 大會報告
2021-11-22~11-25 The Third Cold Spring Harbor Conferences Asia Meeting 大會報告
2020-10-30-11-1 第九屆中國乳腺癌幹細胞高峰論壇 大會報告
2019-11-9~11-10 10th International symposium on DNA Damage Response and Human Diseases. 中國深圳大會報告
2019-06-12~6-13 6th Macau Symposium on Biomedical Sciences 大會報告
2018-06-11~6-15 Cold Spring Harbor Meeting 2018.DNA METABOLISM, GENOMIC STABILITY
& HUMAN DISEASE 大會報告
2017 12-02~12-03 南方科技大學國際腫瘤轉化醫學高峰論壇，中國深圳大會報告
2017 12-01~12-02 第六屆廣州國際腫瘤學會議，中國廣州大會報告
2017 10-27~10-29 8th International symposium on DNA Damage Response and Human Diseases. 中國深圳大會報告
2017 09-21~09-24 第六屆廣州跨學科蛋白質研究會議，中國廣州大會報告
2017 08-18~08-21 第十三屆全國酶學學術讨論會，中國長春大會報告
2017 05-27~05-29 Cullin RING ligases and Protein NEDDylation：Biology and Therapeutics.中國杭州大會報告
2017 05-12~05-14 中華醫學會醫學細胞生物學分會第六次全國學術大會中國西安大會報告.
2016 06-24~06-26 The Second Trilateral Workshop for Frontier Protein Studies. 日本 大阪
大會報告
2016-10-21~10-23 8th International Conference SUMO, Ubiquitin, UBL Proteins：Implications for Human Diseases中國 上海
大會報告：hCINAP, a novel regulator of ubiquitin-like protein modifications in various signaling pathways, is essential for tumor growth
中美腫瘤論壇, 大會報告：hCINAP, an atypical enzyme, is a novel player in tumorigenesis.哈爾濱，2016.1.15-17.
第十四次中國暨國際生物物理大會，分會報告：Human NADPH sensor HSCARG plays important roles in fundamental cellular processes.昆明，2015-11-17.
第十二屆全國酶學學術讨論會，大會報告：腺苷酸激酶hCINAP的結構和功能研究。威海，2015-9-19.
2015蛋白質修飾與降解論壇，大會報告：組蛋白H2A泛素化、類泛素化修飾調控的新機制，上海，2015.6.
The Seventh International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases.大會報告： HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1. 上海，2014.5.
中國生物化學與分子生物學會第十一屆會員代表大會暨2014年全國學術會議，RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair. 廈門，2014.8.
2012年全國生物化學與分子生物學學術大會，報告題目：hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway via controlling NEDDylation of ribosomal protein S14成都， 2012.8.
The 17th IBC (IUPAB). 報告題目：Structural insight into the regulatory mechanism of human UDP-glucose pyrophosphorylase，北京，2011.10.
中國細胞生物學學會第十二次全體會員代表大會暨學術大會. 報告題目：Crystal structure of PACSIN F-BAR domain reveals a novel membrane curvature sensing mechanism.北京，2011.7.
The Inaugural Xiamen Winter Symposium “Molecular Mechanisms and Signalling in Cancer Biology”，報告題目：USP7 deubiquitinates NEMO through the interaction with HSCARG，廈門，2011.2.
2010年中國生物化學與分子生物學會第十屆全國會員代表大會暨全國學術會議. 報告題目：Crystal structure of PACSIN F-BAR domain reveals a novel membrane curvature sensing mechanism. 南京，2010.8.
第三屆中國結構生物學學術讨論會，報告題目：人類分泌蛋白SI-CLP通過巨噬細胞調節固有免疫反應，三亞，2010.3.
21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology（第21屆國際生物化學與分子生物學聯盟學術大會暨第12屆亞洲大洋洲生物化學家與分子生物學家學術大會），上海，2009.8.
2009年北京同步輻射裝置用戶學術年會暨專家會，分會報告：NADPH是HSCARG的變構調節因子，分會報告，太原，2009.8.
10th Sino-Singapore Symposium in Biology，大會報告：HSCARG inhibits activation of NF-κB by interacting with IκB kinase-β. 廈門，2009.11.
第二屆全國“跨學科蛋白質研究”學術讨論會，NADPH sensor protein HSCARG down-regulates NO synthesis and is essential for cell viability. 煙台，2008.7.
北京生物化學學會2007年年會 , 2007.12
International Symposium on Synchrotron Radiation and Biology, Restructuring of the dinucleotide binding fold in a NADP(H) sensor protein, 上海，2007.11
Serum presence of preS antigen in chronic hepatitis B: a significant serological marker in HBV prognosis,Advances in Protein Sciences, Hongkong , 2005.12
Activation of the protein kinase PKR by small double-stranded RNAs flanked by single-stranded regions.,The 3rd Annual Meeting of the China RNA Society & 1st International RNA Workshop in China , 2003.7
Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR,Second International Conference: Proteins that bind RNA , 2001.2

雜志編輯:

2012年-至今 World Journal of Biological Chemistry 編委
2022年-至今 ABBS（生物化學與生物物理學報）編委

教材編撰:

現代分子生物學（第5版），高等教育出版社，朱玉賢，李毅，鄭曉峰，郭紅衛

執教課程:

基礎分子生物學 , 主講, 北京大學, 秋季、2004-至今
研究生科研規範訓練,主持，北京大學, 秋季、2014-至今
蛋白質的翻譯後修飾及其調控作用，主持, 北京大學, 春季、2015-
現代生物學實驗技術原理及其應用，主持, 北京大學, 秋季、2015-
生化與分子生物學進展，主講，北京大學, 秋季、2006-至今
蛋白質晶體學，主講，北京大學, 秋季、2012-2014

      一些參與基本生物學過程的重要蛋白質的功能失調會影響細胞的正常生理功能，并可能導緻炎症、腫瘤在内的多種疾病，因此，對這些蛋白的結構和功能開展研究具有重要的生物學意義。我們實驗室利用生化分子生物學、細胞生物學、免疫學和結構生物學等技術方法，發現并鑒定調控腫瘤細胞生長、炎症和固有免疫性疾病的新的調控蛋白，研究這些蛋白發揮作用的信号通路和分子機制。研究泛素化、類泛素化和磷酸化等蛋白質翻譯後修飾在DNA 損傷應答、炎症、腫瘤發生發展中的調控作用及機制，明确蛋白質功能的失調與炎症、腫瘤等重大疾病的發生和發展的關系。
本實驗室主要興趣在于：
1. 腫瘤發生發展和轉移調控蛋白的篩選、鑒定和分子機制研究
2. DNA損傷修複—基因組穩定性----癌症
3. 病毒--固有免疫—DNA損傷應答—炎症和腫瘤

1.Fu JF, Zhou SR, Xu HL, Liao LM, Shen H, Du P, Zheng XF*. (2023) ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex. Nucleic Acids Res. 51（14）7376-7391.
2.Liao LM, Xu HL, Zhao YH, Zheng XF*. (2023) Metabolic Interventions Combined with CTLA-4 and PD-1/PD-L1 Blockade for the Treatment of Tumors: Mechanisms and Strategies. Frontiers of Medicine. 17(5): 805−822. (Review article).
3.Wei M, Huang XP, Liao LM, Tian YL, Zheng XF*. (2023) SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer. Cancer Research. 83(17):2908-2923.
4.Huang XP, Zhao Y, Wei M, Zhuge RP, Zheng XF*. (2023) hCINAP alleviates senescence through regulating MDM2 status via multiple mechanisms. Journal of Molecular Cell Biology.
Doi: 10.1093/jmcb/mjad015.
5.Zhuge RP, Wang C, Wang J, Yu SY, Liao LM, Zheng XF*. (2023) hCINAP controls lineage differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase separation-mediated YAP1 activation. Cell Reports..42(1) 111935. (Jan 31 2023, https://doi.org/10.1016/j.celrep.2022.111935)
6.Huang XP, Yang YF, Zhu D, Zhao Y, Wei M, Li K, Zu HH. Zheng XF*. (2022) PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα. Cellular and Molecular Life Sciences. 79:319
7.Zhao Y, Huang XP, Zhu D, Wei M, Yu SY, Tian YL, Zheng XF*. (2022) Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Cell Death & Differentiation. 29: 2531–2544. Doi: 10.1038/s41418-022-01036-6.
8.Yu SY, Zang WC, Oiu YC, Liao LM, Zheng XF*. (2022) Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis. Oncogene. 41(1):46-56. DOI:10.1038/s41388-021-02071-2.
9.Xu RD, Yang YF, Zheng XF*. (2021) Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression. FEBS Lett. 595(16): 2071-2084. DOI: 10.1002/1873-3468.14158
10.Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng XF*. (2021) Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1. Cell Death & Differentiation. 28:1773–1789. Doi: 10.1038/s41418-020-00700-z.
11.Yang YF, Yang CZ, Li TT, Yu SY, Cui J, Zheng XF*. (2020) The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults. Cancer Res. 80 (4): 719-731. Dec 24 (online). Doi:10.1158/0008-5472.CAN-19-2149.
12.Zang WC & Zheng XF*. (2020) Structure and Functions of cellular redox sensor HSCARG/NMRAL1, a linkage among redox status, innate immunity, DNA damage response, and cancer. Free Radical Biology and Medicine. 160: 768-774.
13.Zang WC, Yang CZ. Li TT, Liao LM, Zheng XF*. (2019) Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Proc.Natl.Acad.Sci.USA. December 17, 116 (51): 25624-25633. https://doi.org/10.1073/pnas.1910250116
14.Xu RD, Yu SY, Zhu D, Huang XP, Lao YM, Zhang JF, Tang ZF, Zhang ZM, Yi J, Zhu HH, Zhu, Zheng XF*. (2019) hCINAP regulates the DNA damage response and mediates the resistance of acute myelocytic leukemia cells to therapy. Nature Communications.10，3812. Doi.org/10.1038/s41467-019-11795-5.
15.Yang CZ, Zang WC, Ji YP, Li TT, Yang YF, Zheng XF*. (2019) Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly(ADP-ribose) polymerase-dependent manner and regulates the DNA damage response. J Biol Chem. 294(8): 2827-2838. Doi: 10.1074/jbc.RA118.007009
16.Guan JH, Zheng XF*. (2019) NEDDylation regulates RAD18 ubiquitination and localization in response to oxidative DNA damage. Biochemical Biophysical Research Communications. 508: 1240-1244. Doi.org/10.1016/j.bbrc.2018.12.072.
17.Yang CZ, Zang WC, Tang ZF, Ji YP, Xu RD, Yang YF, Luo AP, Hu B, Zhang ZM, Liu ZH, Zheng XF*. (2018) A20 regulates the DNA damage response and mediates tumor cell resistance to DNA damaging therapy. Cancer Research. 78(4): 1069-1082. Doi: 10.1158/0008-5472.CAN-17-2143.
18.Guan JH, Yu SY, Zheng XF*. (2018) NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage. Protein Cell. 9(4):365-379. DOI 10.1007/s13238-017-0455-x.
19.Ji YP, Yang CZ, Tang ZF, Yang YF, Tian YL, Yao HW, Zhu X, Zhang ZM, Ji JF, Zheng XF*. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells in a glycolysis-dependent manner by facilitating LDHA phosphorylation. Nature Communications. 8:15308. Doi.10.1038/ncomms15308.
20.Dong XD, Guan JH, Zheng CF, Zheng XF*. (2017, May 19) The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen. J Biol Chem. 292 (20): 8472-8483. DOI 10.1074/jbc.M117.778076.
21.Bai DM, Zheng XF*. (2017) PML-RARA mutations confer varying arsenic trioxide resistance. Protein & Cell. 8(4):296–301. DOI: 10.1007/s13238-016-0356-4.
22.Yan FX, Guan JH, Peng YY, Zheng XF*. (2017) MyD88 NEDDylation negatively regulates MyD88-dependent NF-κB signaling through antagonizing its ubiquitination. Biochemical and Biophysical Research Communications. 482 (4): 632-637.
23.Bai DM, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao XF, Ji J-F, Zheng XF*. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumor growth. Nature Communications.7: 12310.
24.Qu LL, Ji YP, Zhu X, Zheng XF*. (2015) hCINAP Negatively Regulates NF-κB Signaling by Recruiting the Phosphatase PP1 to Deactivate IKK Complex. Journal of Molecular Cell Biology. 7 (6): 529-542. doi: 10.1093/jmcb/mjv041.
25.Liu Y, Yang YF, Fan JL, He RN, Luo M, Zheng XF*. (2015) The Crystal Structure of PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism. J Biol. Chem. 290(14): 9141-9149.
26.Li TT, Guan J, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG downregulates TNF-induced NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. Cell Difference & Diseases.5: e1229. Doi: 10.1038/cddis.2014.197.
27.Hu B, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acid Res. 42, 5582-5593
28.Li G, Qu L, Ma S, Wu Y, J CW, Zheng XF*. (2014) Structures determination of human Fas Apoptosis Inhibitory Molecule and identification of the critical residues linking the interdomain interaction to the anti-apoptotic activity. Acta crystallographica section D. D70, 1812-1822.
29.Peng YY, Xu RD, Zheng XF*. (2014) HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. PLoS Pathogens. 10(4): e1004041.
30.Li TT, Guan JH, Huang ZJ, Hu X, Zheng XF*. (2014) RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair. J Cell Sci. 127: 2238-2248.
31.Zhang JF, Bai DM, Ma XW, Guan JH, Zheng XF*. (2014) hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14. Oncogene. 33, 246-254. doi: 10.1038/onc.2012.560.
32.Xiao W, Meng G, Zhao Y, Yuan H, Li T, Peng Y, Zhao Y, Luo M, Zhao, WM, Li Z, Zheng XF*. (2014) Human secreted stabilin-1-interacting chitinase-like protein aggravates the inflammation associated with rheumatoid arthritis and is a potential macrophage inflammatory regulator in rodents. ARTHRITIS & RHEUMATOLOGY. 66(5):1141-1152.
33.Bai DM, Zhang J, Xiao WC, Zheng XF*. (2014) Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress. Nucleic Acid Res. 42(3):1799-1811.
34.Meng G, An X, Ye, S, Liu Y, Zhu W, Zhang R, Zheng XF*. (2013) The crystal structure of LidA, a translocated substrate of the Legionella pneumophila Type IV secretion system, reveals a novel folding. Protein & Cell. 4(12):897-900.
35.Bai XY, Zheng XF*. (2013) Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity. Protein & Cell. 4(3): 211–219.
36.Xiao WC, Peng YY, Liu Y, Li Z, Li SL, Zheng XF*. (2013) HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox. PLoS One. 8(3): e59301.
37.Liu Y, Qin K, Meng G, Zhang J, Zhou JF, Zhao GY, Luo M, Zheng XF*. (2013) Structural and Functional Characterization of K339T Substitution Identified in the PB2 subunit Cap-binding Pocket of Influenza A Virus. J Biol. Chem. 288(16): 11013-11023.
38.Liu Y, Meng G, Luo M, Zheng XF*. (2013) Crystallization and X-ray crystallographic analysis on the cap binding domain of influenza A virus H1N1 polymerase subunit PB2. Acta crystallgrophy F. 69: 280-283.
39.Feng X, Yang R, Zheng XF*, Zhang F. (2012) Identification of a novel nuclear-localized adenylate kinase 6 from Arabidopsis thaliana as an essential stem growth factor. Plant Physiol Biochem. 61: 180-186.
40.Bai X, Meng G, Luo,M, Zheng XF*. (2012) Rigidity of the Wedge Loop in PACSIN 3 is a Key Factor in Dictating the Diameters of Tubules. J Biol. Chem. 287(26):22387-22396.
41.Zhang M, Hu B, Li T, Peng Y, Guan J, Lai S, Li Z, Zheng XF*. (2012) A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity. Traffic. 13(6):790-799.
42.Yu Q, Zheng XF*. (2012) The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect important for regulating pyrophosphorylase activity. Biochemical J. 442(2): 283-291.
43.Bai X, Meng G, Zheng XF*. (2012) Cloning, purification, crystallization and preliminary X-ray diffraction analysis of mouse PACSIN 3 protein from Escherichia coli. Acta crystallgrophy F68, 159-162.
44.Zhu WZ, Meng G, Liu Y, Zhang FY, Zheng XF* (2011) Protein Expression, Crystallization and Preliminary X-Ray Crystallographic Studies on LidA from Legionella pneumophila. Acta crystallgrophy F67, 637-639.
45.Li GM, Qiang Chen, Dai KS, Zheng XF*. (2011) The Ca2+-dependent multimerization of Homo sapiens S100 domain in Cornulin protects cells from injury. Progress in Biochemistry and Biophysics. 38(3): ~9.
46.Meng G, Zhao YM, Bai XY, Liu Y, Todd J Green, Luo M, Zheng XF*. (2010) Structure of Human Stabilin-1 Interacting Chitinase-like Protein (SI-CLP) Reveals a Saccharide-binding Cleft with Lower Sugar-binding Selectivity. J Biol. Chem. 285, 39898-39904.
47.Li GM, Qu L, Meng G, Bai Xiaoyun, Dai KS, Zheng XF*. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. (2010). Acta crystallgrophy F. 66: 935-937.
48.Zhang JF, Zhang FY, Zheng XF*. (2010) Deficiency of hCINAP causes defects in Cajal body formation,histone transcription, and cell viability. Cellular and Molecular Life Sciences. 67:1907–1918.
49.Bai XY, Meng G, Li GM, Luo M, Zheng XF*. (2010) Crystallization and preliminary X-ray crystallographic analysis of human PACSIN 1 protein. Acta crystallgrophy F. 66: 73-75.
50.Li GM, Tang ZT, Meng G, Dai KD, Zhao JD, Zheng XF*. (2009) Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from the Anabaena Pcc 7120. Acta crystallgrophy F. 65(10): 1039-1041.
51.Gan QN, Li TT, Hu B, Lian M, Zheng XF* (2009) HSCARG inhibits activation of NF-κB by interacting with IκB kinase-β. J Cell Sci. 122(22): 4081-4088.
52.Heinicke LA, Wong J, Lary J, Nallagatla SR, Diegelman-Parente A, Zheng XF, Cole JL, Philip C Bevilacqua. (2009) RNA dimerization promotes PKR dimerization and activation. J Mol Biol. 390(2): 319-338.
53.Lian M, Zheng XF* (2009) HSCARG regulates NF-κB activation by promoting the ubiquitination of RelA or COMMD1 in response to changes of cellular NADPH/NADP+. J Biol. Chem. 284(27): 17998-18006.
54.Dai XY, Li YY, Meng G, Yao S, Zhao YM, Yu Q, Zhang JF, Luo M and Zheng XF* (2009) NADPH is an allosteric regulator of HSCARG. J Mol. Biol. 387, 1277–1285.
55.Meng G, Bai X, Green TJ, Luo M, Zheng XF* (2009) Crystallization and preliminary X-ray crystallographic studies on SI-CLP, a novel human Glyco_18 domain–containing protein. Protein & Peptide Letter. 16(3): 336-338.
56.Chen B, Lian M, Luo M, Zheng XF* (2008) A chemical lipid modification of recombinant preS antigen to study the mechanism of HBV attachment to the host cell. J Biotechnology. 137: 8-13.
57.Zhao YM, Zhang JF, Li HY, Li YY, Ren J, Luo M and Zheng XF* (2008). An NADPH sensor protein (HSCARG) downregulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. J Biol. Chem. 283(16):11004-11013.
58.Lian M, Zhou X, Chen B, Li C, Gu X, Luo M and Zheng XF* (2008). Identification of the critical regions in HBV preS required for its stability. J Peptide Science. 14(3): 307-312.
59.Nallagatla SR, Hwang J, Toroney R, Zheng XF, Cameron CE and Bevilacqua PC. (2007) 5`-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science, 318: 1455-1458.
60.Chen Q, You DL, Liang YH, Su XD, Gu X, Luo M and Zheng XF* (2007). Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design. FEBS J. 274: 4408-4415.
61.Zheng XF*, Dai XY, Zhao YM, Chen Q, Lu F, Yao DQ, Yu Q, Liu XP, Zhang CM, Gu X and Luo M* (2007). Restructuring of the dinucleotide binding fold in a NADP(H) sensor protein. Proc.Natl.Acad.Sci.USA. 104(21): 8809-8814.
62.Lian M, Zhou X, Wei L, Qiu SH, Zhou T, Li L, Gu X, Luo M and Zheng XF* (2007). Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients. Virology J. 4: 93.
63.Li CY, Yu Q, Ye ZQ, Sun Y, He QY, Li XM, Zhang WX, Luo JC, Gu X, Zheng XF* and Wei LP* (2007). A Nonsynonymous SNP in Human Cytosolic Sialidase in a Small Asian Population Results in Reduced Enzyme Activity: Potential Link with Severe Adverse Reactions to Oseltamivir. Cell Research. 17(4):357-362.
64.Dai X, Gu X, Luo M and Zheng XF* (2006). Protein expression, crystallization and preliminary X-ray crystallographic studies on HSCARG from Homo sapiens. Protein & Peptide Letter. 13(9):955-957.
65.Zhai RT, Meng G, Zhao YM, Liu B, Zhang GF and Zheng XF* (2006). A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans. FEBS Letters. 580: 3811-3817.
66.Chen Q, Hui R, Sun C, Gu X, Luo M and Zheng XF* (2006). Soluble expression, purification, and stabilization of a pro-apoptotic human protein, CARP. Protein Expression & Purification. 45(2):329-334.
67.Yu YM, Li L, Zheng XF, Liang YH and Su XD (2006). Protein Preparation, Crystallization and Preliminary X-ray Analysis of Imidazolonepropionase from Bacillus subtilis. BBA - Proteins and Proteomics. 1764, 153-156.
68.Dai X, Chen Q, Lian M, Zhou Y, Zhou M, Lu SY, Chen YJ, Luo JC, Gu X, Jiang Y, Luo M and Zheng XF* (2005). Systematic high-yield production of human secreted proteins in Escherichia coli. Biochem Biophys Research Commun 332: 593-601.
69.Chen Q, Liang YH, Su XD, Gu X, Zheng XF and Luo M (2005). Alternative IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis. J. Mol. Biol. 348(5):1199-1210.
70.Ren H, Wang LY, Bennett M, Liang YH, Zheng XF, Lu F, Li LF, Luo M, Eriksson S,. Zhang CM and Su XD (2005). The crystal structure of human adenylate kinase 6: an adenylate kinase isoform localized to the cell nucleus. Proc.Natl.Acad.Sci.USA. 102 (2):303-8.
71.Zheng XF and Bevilacqua PC (2004) A novel class of activators of PKR: small double-stranded RNAs with single-stranded tails. RNA 10:1934-1945.
72.Ren H, LiangYH, Li R, Ding H, Qiu S, Lu S, An J, Li L, Luo M, Zheng XF* and Su, XD (2004). Protein preparation, crystallization and preliminary X-ray analysis of human adrenal gland protein AD-004. Acta Cryst D60: 1292-1294.
73.Zheng XF and Bevilacqua PC (2001). Efficient construction of long DNA duplexes with internal non-Watson-Crick motifs and modifications. Nucleic Acids Res. 29(2) e6.
74.Zheng XF and Bevilacqua PC. (2000). Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR. Proc.Natl.Acad.Sci.USA 97(26):14162-14167.
75.Zheng XF, Kobayashi Y and Takeuchi M (1998). Construction of a low serine-type carboxypeptidase producing mutant of Aspergillus oryzae by the expression of antisense RNA and its use as a host for heterologous protein secretion. Appl. Microbiol. Biotechnology. 49:39-44.
76.Zheng XF and Huang BQ. (1994) Marker proteins for somatic embryogenesis in several plants. Acta Bontanica Sinica. 36(3):175-180.
77.Zheng XF & Huang, BQ. (1994). Intranuclear and cytoplasmic inclusions in embryogenic and embryoidal cells of Panax quinquefolius. Acta Bontanica Sinica. 36(1):73-74.
78.Zhang GF, Huang BQ, Zheng XF, and Hao S (1993). Plant regeneration from protoplasts derived from suspension cultures in Leymus Racemosus. Acta Bontanica Sinica. 35(6): 422-428.
79.Wang L, Zheng XF & Zhang GF (1990). Rapid propagation of Leymus giganteus L., Plant Physiology Communications. 3:47-48.
80.李智; 劉勇; 鄭曉峰; 張飛雲（2011）MNDA及MNDA-HIN200片段在大腸杆菌中克隆、表達及純化，生物技術通報，8：181-186.
81.任雨蒙，賈瑩瑩，石程，付旻，廖禮銘，鄭曉峰*，韓紅敬*. （2021）. 胚胎移植前宮腔液外泌體提取及其對妊娠結局的影響分析. 生殖醫學雜志. 30(08): 1008-1014.
82.廖禮銘，趙燕，鄭曉峰*. 2018. 外泌體在白血病中的重要調控作用. 中國生物化學與分子生物學報. 34(03): 240-248.
83.15. 諸葛瑞鵬, 黃新平, 鄭曉峰*. 非典型腺苷酸激酶AK6/hCINAP的結構和功能[J]. 生物化學與生物物理進展, 2023, 50(5):1122-1132.

主要研究方向包括鑒定影響腫瘤發生發展和轉移調控的新蛋白，揭示泛素化、類泛素化、乙酰化等蛋白質翻譯後修飾在DNA損傷應答、腫瘤細胞耐藥、腫瘤代謝、免疫調控中的作用和分子機制。先後主持和承擔了國家自然科學基金生命學部和醫學部重點項目（3）、面上項目（7），國際合作ICGEB課題（2），教育部博士點優先發展基金、科技部863、973、國家重大科學研究計劃近二十個項目的研究。

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