執教課程:
本科生“生理學”
本科生“高級神經生物學”
研究生“神經生物學”
研究生“感覺神經生物學進展”
CLS/PTN研究生“神經生物學”
交叉學院研究生“生物物理” 神經科學的核心目标是闡明感知、行為和意識等産生的神經機制。
利用果蠅、小鼠和非人靈長類等多種模式動物，我們研究以上過程：1) 視覺“暗光”的分子機制 (Science, 2011; Nature Neuroscience，2008； Current Biology, 2020); 2) 嗅覺編碼機制 (PNAS, 2016； Nature Communications, 2017); 3) 機械感知對進食決策的調控 (Science Advances, 2019); 4) 生物鐘的神經機制 (Nature Communications, 2018； Science Advances, 2022; Nature 2023)。
我們發展了國際前沿的神經電生理技術（包括活體動物腦的多電極膜片鉗記錄），結合分子遺傳、光遺傳和雙光子鈣成像等，揭示大腦産生感知和行為的基本規律。目前，正在進行的研究課題包括：(1) 感覺信号編碼和加工的神經機制；(2) 進食等本能行為的神經機制; (3) 生物鐘和睡眠的神經機制。
1. Xiao N, Xu S, Li ZK, Tang M, Mao R, Yang T, Ma SX, Wang PH, Li MT, Sunikumar A, Rouyer F, Cao LH, and Luo DG. (2023) A single photoreceptor splits perception and entrainment by cotransmission. Nature 623, 562-570.
2. Tang M, Cao LH, Yang T, Ma SX, Jing BY, Xiao N, Xu S, Leng KR, Yang D, Li MT, Luo DG.(2022) An extra-clock ultradian brain oscillator sustains circadian timekeeping. Science Advances 8, eabo5506.
3. Luo DG, Silverman D, Frederiksen R, Adhikari R, Cao LH, Oatis JE, Kono M, Cornwall MC, and Yau KW. (2020) Apo-opsin and its dark constitutive activity across retinal cone subtypes. Current Biology 30: 4921-4931.
4. Wu F, Deng B, Xiao N, Wang T, Li Y, Wang R, Shi K, Luo DG, Rao Y, Zhou C. (2020) A neuropeptide regulates fighting behavior in Drosophila melanogaster. Elife e54229.
5. Zhou Y, Cao LH, Sui XW, Guo XQ, and Luo DG. Mechanosensory circuits coordinate two opposing motor actions in Drosophila feeding. Science Advances 2019, 5: eaaw5141.
6. Li MT, Cao LH, Xiao N, Tang M, Deng B, Yang T, Yoshii T, and Luo DG. Hub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila. Nature Communications 2018, 9: 4247.
7. Cao LH, Yang D, Wu W, Zeng X, Jing BY, Li MT, Qin SS, Tang C, Tu Y, and Luo DG. Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila. Nature Communications 2017, 8: 1357.
8. Yue WW, Frederiksen R, Ren X, Luo DG, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. eLife, 2017, 6. pii: e18492.
9. Cao LH, Jing BY, Yang D, Zeng X, Shen Y, Tu Y and Luo DG. Distinct signaling of Drosophila chemoreceptors in olfactory sensory neurons. Proc. Natl. Acad. Sci. USA, 2016, 113, E902-E911.
10. Cao LH, Luo DG and Yau KW. Light responses of primate and other mammalian cones. Proc. Natl. Acad. Sci. USA, 2014, 111, 2752-2757.
11. Luo DG*, Yue WWs, Ala-Laurila P and Yau KW*. Activation of visual pigments by light and heat. Science, 2011, 332, 1037-1032. (*Co-corresponding Authors)
12. Fu Y*, Kefalov VJ*, Luo DG*, Xue T* and Yau KW. Quantal noise from human red cone pigment. Nature Neuroscience, 2008, 11, 565-571. (*Equal Contributions)
13. Luo DG, Xue T, and Yau KW. How vision begins: an odyssey. Proc. Natl. Acad. Sci. USA, 2008, 105, 9855-9862.
14. Su CY, Luo DG, Terakita A, Schichida Y, Liao HW, Kazmi MA, Sakamar TP and Yau KW. Parietal-eye phototransduction components and their potential evolutionary implications. Science, 2006, 311, 11617-11621.
15. Luo DG and Yau KW. Rod sensitivity of neonatal mouse and rat. J. Gen. Physiol., 2005, 126, 263-269.
16. Fu YB, Zhong HN, Wang MH, Luo DG, Liao HW, Maeda H, Hattar S, Frishman LJ and Yau KW. Intrinsically photosensitive retinal ganglion cells detect light with a Vitamin A-based photopigment, melanopsin. Proc. Natl. Acad. Sci. USA, 2005, 102, 10339-10344.
17. Huttl S, Michalakis S, Seeliger M, Luo DG, Acar N, Geiger H, Hudl K, Mader R, Haverkamp S, MOser M, Pfeifer A, Gerstner A, Yau KW and Beil M. Impaired channel targeting and retinal degeneration i mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J. Neurosci., 2005, 25, 130-138.
18. Luo DG, Li GL and Yang XL. Zn2+ modulates light responses of color-opponent bipolar and amacrine cells in the carp retina. Brain Res. Bull., 2002, 58, 461-468.
19. Luo DG and Yang XL. Suppression by zinc of transient OFF responses of carp amacrine cells to red light is mediated by GABAa receptors. Brain Res., 2002, 958, 222-226.
20. Luo DG and Yang XL. Zn2+ differentially modulates signals from red- and short-wavelenth-sensitive cones to horizontal cells in carp reitna. Brain Res., 2001, 900, 95-102.
21. Xu HP, Luo DG and Yang XL. Signals from cone photoreceptors to L-tyoe horizontal cells are differntially modulated by low calcium in carp retina. Eur. J. Neurosci., 2001, 13, 1411-1419.
神經科學的核心目标是闡明感知、行為和意識等産生的神經機制。
利用果蠅、小鼠和非人靈長類等多種模式動物，我們研究以上過程：1) 視覺“暗光”的分子機制 (Science, 2011; Nature Neuroscience，2008； Current Biology, 2020); 2) 嗅覺編碼機制 (PNAS, 2016； Nature Communications, 2017); 3) 機械感知對進食決策的調控 (Science Advances, 2019); 4) 生物鐘的神經機制 (Nature Communications, 2018； Science Advances, 2022; Nature 2023)。
我們發展了國際前沿的神經電生理技術（包括活體動物腦的多電極膜片鉗記錄），結合分子遺傳、光遺傳和雙光子鈣成像等，揭示大腦産生感知和行為的基本規律。目前，正在進行的研究課題包括：(1) 感覺信号編碼和加工的神經機制；(2) 進食等本能行為的神經機制; (3) 生物鐘和睡眠的神經機制。
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