個人介紹:

鄧宏魁，北京大學博雅講席教授、長江學者特聘教授，北京大學幹細胞研究中心主任，清華-北大生命科學聯合中心高級研究員，國家傑出青年科學基金獲得者，973項目和國家重點研發計劃首席科學家。課題組長期以來緻力于開發調控細胞命運的新方法和建立多潛能幹細胞制備的全新底層技術，累計發表論文160餘篇，被引用16,000餘次，尤其在小分子化合物誘導細胞命運轉變方面做出了一系列開拓性工作：1）首次實現完全使用小分子化合物逆轉“發育時鐘”，讓小鼠體細胞重新獲得多潛能性（Science, 2013），在後續的研究工作中揭示了化學重編程全新的分子機制（Cell, 2015; Cell Stem Cell, 2018），一系列成果開創了全新的體細胞重編程體系；2) 首次實現完全使用小分子化合物誘導人類體細胞轉變為多潛能幹細胞（hCiPS細胞）（Nature, 2022），是我國從源頭上獨創的新一代多潛能幹細胞制備技術；3）利用小分子化合物建立了一種全新的具有全能性特征的幹細胞（EPS細胞）（Cell, 2017），從小鼠2細胞胚胎建立了新型全能性幹細胞（TPS細胞）（Cell Res, 2022）；4）利用小分子化合物實現功能成熟細胞在體外的長期維持（Science, 2019），從多潛能幹細胞誘導制備功能成熟的肝細胞，在急性肝衰豬模型上成功完成了人工肝治療的動物實驗；從多潛能幹細胞高效分化制備功能成熟的胰島細胞，在糖尿病小鼠和猴模型上驗證了有效性和安全性（Nature Medicine, 2022）；5）實現小分子化合物誘導小鼠體細胞成為功能性神經元（Cell Stem Cell, 2015），并實現了在成年小鼠大腦中将體細胞原位轉變神經元的體内重編程（Cell Discov, 2021）。

教育經曆:

1990 - 1995 , 理學博士 , UCLA
1984 - 1987 , 理學碩士 , 上海第二醫科大學
1980 - 1984 , 理學學士 , 武漢大學

工作經曆:

1995-1997 美國紐約大學醫學中心Skirball Institute，博士後研究
1998-2000 美國麻省ViaCell 公司，分子生物學主任
2001-至今　　北京大學，特聘教授
2011-至今　　北大-清華生命科學中心，高級研究員　　　　　　　　　　　　　　　　　　　　　　　　　　
2013-至今　　北京大學幹細胞研究中心，主任
2016-至今　　 北京大學博雅講座教授

榮譽獎勵:

北京市科學技術一等獎（2011年）
藥明康德生命化學研究傑出成就獎（2013年）
第七屆“談家桢生命科學獎”（2014年），
第十八屆吳階平-保羅·楊森醫學藥學獎（2017年）
中國幹細胞年會幹細胞傑出貢獻獎（2018年）
中國細胞生物學學會傑出成就獎（2019年）
北京大學國華傑出學者獎（2019年）

學術任職:

2010-2016 Board of Director, International Society for Stem Cell Research
2021-至今Board of Director, International Society for Regenerative Biology

　　

雜志任職:

2013- Editorial Board Member, Cell 2013- Editorial Board Member, Cell Stem Cell 2013- Editorial Board Member, Stem Cell Report, 2010- Editorial Board Member, Cell Research

      本實驗室主要興趣在于體細胞重編程、細胞命運調控和再生醫學應用研究。我們的主要研究方向是如何通過細胞命運調控獲得多潛能幹細胞和各種功能性細胞。生命的本質是化學過程，化學小分子調控細胞命運理論上是最有效的方式。我們研究團隊建立了化學小分子調控細胞命運的技術手段，首次利用化學小分子将小鼠體細胞誘導成為多潛能幹細胞和功能性神經元，首次實現完全利用化學小分子制備人多潛能幹細胞，不僅有助于更好地理解細胞命運決定和轉變機制，而且為未來再生醫學治療重大疾病帶來新的可能。我們團隊利用化學小分子首次在體外建立了具有全能性特征的幹細胞（EPS細胞），該細胞具有更強的發育潛能，為體外制備各種功能成熟的細胞類型提供了更好的來源。我們将利用多潛能幹細胞定向分化制備功能性的血液細胞、胰島細胞、肝髒細胞，并結合基因編輯技術制備新型抗腫瘤的CAR-T細胞，為治療重大疾病提供新的解決方案。

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