北京大學定量生物學中心

學術報告  

題    目: The Regulation of Focal Adhesion Dynamics

報告人: 餘聰 博士

長聘副教授，南方科技大學beat365

時  間: 12月18日（周一）13:00-14:00

地    點: 呂志和樓B101

主持人: 齊志 研究員

摘要:

Animal cells live in an environment called extra-cellular matrix (ECM). The interactions between the cells and ECM play fundamental roles in development and in adult organisms by controlling cell adhesion, migration, proliferation, survival, differentiation, and matrix assembly. Transmembrane receptor integrin-mediated focal adhesion (FA) is one of the most important cell-ECM adhesions. FAs are highly complex structures consisting of hundreds of different proteins and undergo dynamic assembly and disassembly. By linking to cytoskeletons, FAs can morphologically respond to mechanical force and thereby alter cell adhesion and mobility. Here, I will present our recently work about how protein interaction, mechanical force sensing, and phase separation orchestrate to regulate FA assembly and disassembly.

報告人簡介：

餘聰，中國科學技術大學學士、香港科技大學博士。目前任職南方科技大學beat365副教授（長聘）。國家青年千人， 深圳市海外高層次人才。 課題組緻力于研究細胞與細胞外微環境的相互作用，采用結構生物學、生物化學和細胞生物學的方法研究細胞黏附結構的形成及信号傳導的分子機制，以及細胞骨架及分子馬達的調控機制，理解它們在生理和病理過程中發揮功能的分子機理。作為主要作者在Cell、Mol Cell、Science Advances、PNAS、Cell Reports、Elife 等雜志發表多篇研究論文。